Gut Microbiota Orchestrates Energy Homeostasis during Cold

被引：598

作者：

Chevalier, Claire ^{[1
,2
]}

Stojanovic, Ozren ^{[1
,2
]}

Colin, Didier J. ^{[3
]}

Suarez-Zamorano, Nicolas ^{[1
,2
]}

Tarallo, Valentina ^{[1
,2
]}

Veyrat-Durebex, Christelle ^{[1
,2
]}

Rigo, Dorothee ^{[1
,2
]}

Fabbiano, Salvatore ^{[1
,2
]}

Stevanovic, Ana ^{[1
,2
]}

Hagemann, Stefanie ^{[4
]}

Montet, Xavier ^{[5
]}

Seimbille, Yann ^{[3
]}

Zamboni, Nicola ^{[6
]}

Hapfelmeier, Siegfried ^{[4
]}

Trajkovski, Mirko ^{[1
,2
,7
]}

机构：

[1] Univ Geneva, Fac Med, Ctr Med Univ CMU, Dept Cell Physiol & Metab, CH-1211 Geneva, Switzerland

[2] Univ Geneva, Ctr Diabet, Fac Med, CH-1211 Geneva, Switzerland

[3] Univ Hosp Geneva, Ctr BioMed Imaging CIBM, CH-1211 Geneva, Switzerland

[4] Univ Bern, Inst Infect Dis, CH-3010 Bern, Switzerland

[5] Univ Hosp Geneva, Div Radiol, CH-1211 Geneva, Switzerland

[6] Swiss Fed Inst Technol, Inst Mol Syst Biol, CH-8093 Zurich, Switzerland

[7] Univ Coll London UCL, Inst Struct & Mol Biol, Div Biosci, London WC1E 6BT, England

来源：

CELL | 2015年 / 163卷 / 06期

基金：

欧洲研究理事会; 瑞士国家科学基金会;

关键词：

BROWN ADIPOSE-TISSUE; OBESITY; ADIPOCYTES; FAT; PROTEIN; MOUSE; MICE;

D O I：

10.1016/j.cell.2015.11.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microbial functions in the host physiology are a result of the microbiota-host co-evolution. We show that cold exposure leads to marked shift of the microbiota composition, referred to as cold microbiota. Transplantation of the cold microbiota to germ-free mice is sufficient to increase insulin sensitivity of the host and enable tolerance to cold partly by promoting the white fat browning, leading to increased energy expenditure and fat loss. During prolonged cold, however, the body weight loss is attenuated, caused by adaptive mechanisms maximizing caloric uptake and increasing intestinal, villi, and microvilli lengths. This increased absorptive surface is transferable with the cold microbiota, leading to altered intestinal gene expression promoting tissue remodeling and suppression of apoptosis-the effect diminished by co-transplanting the most cold-downregulated strain Akkermansia muciniphila during the cold microbiota transfer. Our results demonstrate the microbiota as a key factor orchestrating the overall energy homeostasis during increased demand.

引用

页码：1360 / 1374

页数：15

共 35 条

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