Dosimetry of very high energy electrons (VHEE) for radiotherapy applications: using radiochromic film measurements and Monte Carlo simulations

被引：46

作者：

Subiel, A. ^{[1
]}

Moskvin, V. ^{[2
]}

Welsh, G. H. ^{[1
]}

Cipiccia, S. ^{[1
]}

Reboredo, D. ^{[1
]}

Evans, P. ^{[3
]}

Partridge, M. ^{[4
]}

DesRosiers, C. ^{[5
]}

Anania, M. P. ^{[6
]}

Cianchi, A. ^{[7
]}

Mostacci, A. ^{[6
]}

Chiadroni, E. ^{[6
]}

Di Giovenale, D. ^{[6
]}

Villa, F. ^{[6
]}

Pompili, R. ^{[6
]}

Ferrario, M. ^{[6
]}

Belleveglia, M. ^{[6
]}

Di Pirro, G. ^{[6
]}

Gatti, G. ^{[6
]}

Vaccarezza, C. ^{[6
]}

Seitz, B. ^{[8
]}

Isaac, R. C. ^{[9
]}

Brunetti, E. ^{[1
]}

Wiggins, S. M. ^{[1
]}

Ersfeld, B. ^{[1
]}

Islam, M. R. ^{[1
]}

Mendonca, M. S. ^{[5
]}

Sorensen, A. ^{[10
]}

Boyd, M. ^{[10
]}

Jaroszynski, D. A. ^{[1
]}

机构：

[1] Univ Strathclyde, Scottish Univ Phys Alliance, Dept Phys, Glasgow G4 0NG, Lanark, Scotland

[2] Purdue Univ, Sch Hlth Sci, W Lafayette, IN 47907 USA

[3] Univ Surrey, Fac Engn & Phys Sci, Guildford GU2 7XH, Surrey, England

[4] Univ Oxford, Dept Oncol, Oxford OX3 7DQ, England

[5] Indiana Univ Sch Med, Dept Radiat Oncol, Indianapolis, IN 46202 USA

[6] Ist Nazl Fis Nucl, Lab Nazl Frascati, Rome, Italy

[7] Ist Nazl Fis Nucl, Rome, Italy

[8] Univ Glasgow, Sch Phys & Astron, Glasgow G12 8QQ, Lanark, Scotland

[9] Mar Athanasius Coll, Kothamangalam 686666, Kerala, India

[10] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G1 1XQ, Lanark, Scotland

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2014年 / 59卷 / 19期

基金：

英国工程与自然科学研究理事会;

关键词：

very high energy electrons; film dosimetry; Monte Carlo; EBT2; EBT2; FILM; GAFCHROMIC FILMS; WIDE-RANGE; PROTON; BEAMS; DEPENDENCE; PHOTON; THERAPY; FLUKA;

D O I：

10.1088/0031-9155/59/19/5811

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Very high energy electrons (VHEE) in the range from 100-250 MeV have the potential of becoming an alternative modality in radiotherapy because of their improved dosimetry properties compared with MV photons from contemporary medical linear accelerators. Due to the need for accurate dosimetry of small field size VHEE beams we have performed dose measurements using EBT2 Gafchromic (R) film. Calibration of the film has been carried out for beams of two different energy ranges: 20 MeV and 165 MeV from conventional radio frequency linear accelerators. In addition, EBT2 film has been used for dose measurements with 135 MeV electron beams produced by a laser-plasma wakefield accelerator. The dose response measurements and percentage depth dose profiles have been compared with calculations carried out using the general-purpose FLUKA Monte Carlo (MC) radiation transport code. The impact of induced radioactivity on film response for VHEEs has been evaluated using the MC simulations. A neutron yield of the order of 10(-5) neutrons cm(-2) per incident electron has been estimated and induced activity due to radionuclide production is found to have a negligible effect on total dose deposition and film response. Neutron and proton contribution to the equivalent doses are negligible for VHEE. The study demonstrates that EBT2 Gafchromic film is a reliable dosimeter that can be used for dosimetry of VHEE. The results indicate an energy-independent response of the dosimeter for 20 MeV and 165 MeV electron beams and has been found to be suitable for dosimetry of VHEE.

引用

页码：5811 / 5829

页数：19

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