Synthesis and evaluation of 9-deoxy analogues of (-)-thysanone, an inhibitor of HRV 3C protease

被引：15
|
作者：
Jeong, Joo Young [1 ,2 ]
Sperry, Jonathan [1 ]
Taylor, John A. [2 ]
Brimble, Margaret A. [1 ,3 ]
机构：
[1] Univ Auckland, Sch Chem Sci, Auckland 1142, New Zealand
[2] Univ Auckland, Sch Biol Sci, Auckland 1010, New Zealand
[3] Univ Auckland, Maurice Wilkins Ctr Mol Biodiscovery, Auckland Mail Ctr, Auckland 1142, New Zealand
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2014年 / 87卷
关键词：
HRV 3C protease; Inhibitor; Pyranonaphthoquinone; Thysanone; C-H activation; 3C-PROTEASE INHIBITOR; BIOLOGICAL EVALUATION; HUMAN RHINOVIRUSES; FORMAL SYNTHESIS; DEOXY ANALOGS; THYSANONE; EFFICIENT; STEREOCHEMISTRY; INFECTIONS; QUINONES;
D O I：
10.1016/j.ejmech.2014.09.063
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
9-Deoxy analogues of the HRV 3C protease inhibitor (-)-thysanone display better inhibitory properties than the natural product, inferring the C9-OH hinders binding to the enzyme. (C) 2014 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：220 / 227
页数：8
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