IPEX and the role of FOXP3 in the development and function of human Tregs

被引：59

作者：

Le Bras, Severine

Geha, Raif S.

机构：

[1] Harvard Univ, Div Immunol, Childrens Hosp, Sch Med, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2006年 / 116卷 / 06期

关键词：

D O I：

10.1172/JCI28880

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Genetic defects in the transcription factor forkhead box protein P3 (FOXP3) cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX). IPEX is thought to be due to a defect in naturally arising CD4(+) Tregs. In this issue of the JCI, Bacchetta and colleagues demonstrate that patients with IPEX and missense mutations in FOXP3 provide insight into the role of various domains of FOXP3 in the development and function of Tregs (see the related article beginning on page 1713).

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页码：1473 / 1475

页数：3

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