The role of Micro-RNAs in Hepatocellular Carcinoma: From Molecular Biology to Treatment

被引：50

作者：

D'Anzeo, Marco ^{[1
]}

Faloppi, Luca ^{[1
]}

Scartozzi, Mario ^{[1
]}

Giampieri, Riccardo ^{[1
]}

Bianconi, Maristella ^{[1
]}

Del Prete, Michela ^{[1
]}

Silvestris, Nicola ^{[2
]}

Cascinu, Stefano ^{[1
]}

机构：

[1] Univ Politecn Marche, Dept Med Oncol, AOU Osped Riuniti, I-60126 Ancona, Italy

[2] IRCSS Osped Oncol Bari, Ist Oncol Giovanni Paolo 2, I-70124 Bari, Italy

来源：

MOLECULES | 2014年 / 19卷 / 05期

关键词：

HCC; hepatocellular carcinoma; miRNAs; ALPHA-FETOPROTEIN EXPRESSION; UP-REGULATION; SUPPRESSOR GENE; DOWN-REGULATION; CANCER; TARGETS; LIVER; IDENTIFICATION; PROTEIN; HEPATOCARCINOGENESIS;

D O I：

10.3390/molecules19056393

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third leading cause of cancer deaths. microRNAs (miRNAs) are evolutionary conserved small non-coding RNA that negatively regulate gene expression and protein translation. Recent evidences have shown that they are involved in many biological processes, from development and cell-cycle regulation to apoptosis. miRNAs can behave as tumor suppressor or promoter of oncogenesis depending on the cellular function of their targets. Moreover, they are frequently dysregulated in HCC. In this review we summarize the latest findings of miRNAs regulation in HCC and their role as potentially diagnostic and prognostic biomarkers for HCC. We highlight development of miRNAs as potential therapeutic targets for HCC.

引用

页码：6393 / 6406

页数：14

共 80 条

[1] Promising Candidate Urinary MicroRNA Biomarkers for the Early Detection of Hepatocellular Carcinoma among High-Risk Hepatitis C Virus Egyptian Patients
Abdalla, Moemen A. K.
Haj-Ahmad, Yousef
[J]. JOURNAL OF CANCER, 2012, 3 : 19 - 31
[2] A functional polymorphism in pre-microRNA-196a-2 contributes to the susceptibility of hepatocellular carcinoma in a Turkish population: a case-control study
Akkiz, H.
Bayram, S.
Bekar, A.
Akgollu, E.
Ulger, Y.
[J]. JOURNAL OF VIRAL HEPATITIS, 2011, 18 (07) : E399 - E407
[3] The Promise of MicroRNA Replacement Therapy
Bader, Andreas G.
Brown, David
Winkler, Matthew
[J]. CANCER RESEARCH, 2010, 70 (18) : 7027 - 7030
[4] MicroRNA-122 Inhibits Tumorigenic Properties of Hepatocellular Carcinoma Cells and Sensitizes These Cells to Sorafenib
Bai, Shoumei
Nasser, Mohd W.
Wang, Bo
Hsu, Shu-Hao
Datta, Jharna
Kutay, Huban
Yadav, Arti
Nuovo, Gerard
Kumar, Pawan
Ghoshal, Kalpana
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (46) : 32015 - 32027
[5] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004)
Bartel, David P.
[J]. CELL, 2007, 131 (04) : 11 - 29
[6] MicroRNA control of lifespan and metabolism
Boehm, Michelle
Slack, Frank J.
[J]. CELL CYCLE, 2006, 5 (08) : 837 - 840
[7] Identification of metastasis-related microRNAs in hepatocellular carcinoma
Budhu, Anuradha
Jia, Hu-Liang
Forgues, Marshonna
Liu, Chang-Gong
Goldsteir, David
Lam, Amy
Zanetti, Krista A.
Ye, Qing-Hai
Qin, Lun-Yju
Croce, Carlo M.
Tang, Zhao-You
Wang, Xin Wei
[J]. HEPATOLOGY, 2008, 47 (03) : 897 - 907
[8] microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma
Burchard, Julja
Zhang, Chunsheng
Liu, Angela M.
Poon, Ronnie T. P.
Lee, Nikki P. Y.
Wong, Kwong-Fai
Sham, Pak C.
Lam, Brian Y.
Ferguson, Mark D.
Tokiwa, George
Smith, Ryan
Leeson, Brendan
Beard, Rebecca
Lamb, John R.
Lim, Lee
Mao, Mao
Dai, Hongyue
Luk, John M.
[J]. MOLECULAR SYSTEMS BIOLOGY, 2010, 6
[9] MicroRNA functions
Bushati, Natascha
Cohen, Stephen M.
[J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2007, 23 : 175 - 205
[10] MicroRNAs and cell cycle regulation
Carleton, Michael
Cleary, Michele A.
Linsley, Peter S.
[J]. CELL CYCLE, 2007, 6 (17) : 2127 - 2132

← 1 2 3 4 5 6 7 8 →