Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes

被引：14
作者：
Booth, Lauren N. [1 ]
Maures, Travis J. [1 ,3 ]
Yeo, Robin W. [1 ]
Tantilert, Cindy [1 ]
Brunet, Anne [1 ,2 ]
机构：
[1] Stanford Univ, Dept Genet, Stanford, CA 94305 USA
[2] Stanford Univ, Glenn Labs Biol Aging, Stanford, CA 94305 USA
[3] Synthego, Redwood City, CA USA
来源：
ELIFE | 2019年 / 8卷
基金：
美国国家卫生研究院;
关键词：
MULTIPLE SEQUENCE ALIGNMENT; OOCYTE MEIOTIC MATURATION; LIFE-SPAN; ELEGANS HERMAPHRODITES; NATURAL-POPULATIONS; DETERMINATION GENE; FAT-METABOLISM; STEM-CELLS; CAENORHABDITIS; LONGEVITY;
D O I：
10.7554/eLife.46418
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Sexual interactions have a potent influence on health in several species, including mammals. Previous work in C. elegans identified strategies used by males to accelerate the demise of the opposite sex (hermaphrodites). But whether hermaphrodites evolved counter-strategies against males remains unknown. Here we discover that young C. elegans hermaphrodites are remarkably resistant to brief sexual encounters with males, whereas older hermaphrodites succumb prematurely. Surprisingly, it is not their youthfulness that protects young hermaphrodites, but the fact that they have self-sperm. The beneficial effect of self-sperm is mediated by a sperm-sensing pathway acting on the soma rather than by fertilization. Activation of this pathway in females triggers protection from the negative impact of males. Interestingly, the role of self-sperm in protecting against the detrimental effects of males evolved independently in hermaphroditic nematodes. Endogenous strategies to delay the negative effect of mating may represent a key evolutionary innovation to maximize reproductive success.
引用
收藏
页数：24
相关论文
共 95 条
[21]   Analysis of Male Pheromones That Accelerate Female Reproductive Organ Development [J].
Flanagan, Kelly A. ;
Webb, William ;
Stowers, Lisa .
PLOS ONE, 2011, 6 (02)
[22]   A COST OF MATING IN FEMALE FRUIT-FLIES [J].
FOWLER, K ;
PARTRIDGE, L .
NATURE, 1989, 338 (6218) :760-761
[23]   C. elegans outside the Petri dish [J].
Frezal, Lise ;
Felix, Marie-Anne .
ELIFE, 2015, 4
[24]   Neural mechanisms of social learning in the female mouse [J].
Gao, Yuan ;
Budlong, Carl ;
Durlacher, Emily ;
Davison, Ian G. .
ELIFE, 2017, 6
[25]   Diversity in mating behavior of hermaphroditic and male-female caenorhabditis nematodes [J].
Garcia, L. Rene ;
LeBoeuf, Brigitte ;
Koo, Pamela .
GENETICS, 2007, 175 (04) :1761-1771
[26]   Male Presence can Increase Body Mass and Induce a Stress-Response in Female Mice Independent of Costs of Offspring Production [J].
Garratt, Michael ;
Kee, Anthony J. ;
Palme, Rupert ;
Brooks, Robert C. .
SCIENTIFIC REPORTS, 2016, 6
[27]   Longevity in Caenorhabditis elegans reduced by mating but not gamete production [J].
Gems, D ;
Riddle, DL .
NATURE, 1996, 379 (6567) :723-725
[28]   Drosophila Life Span and Physiology Are Modulated by Sexual Perception and Reward [J].
Gendron, Christi M. ;
Kuo, Tsung-Han ;
Harvanek, Zachary M. ;
Chung, Brian Y. ;
Yew, Joanne Y. ;
Dierick, Herman A. ;
Pletcher, Scott D. .
SCIENCE, 2014, 343 (6170) :544-548
[29]   Carbonylated proteins are eliminated during reproduction in C-elegans [J].
Goudeau, Jerome ;
Aguilaniu, Hugo .
AGING CELL, 2010, 9 (06) :991-1003
[30]   TARGETED MUTATIONS IN THE CAENORHABDITIS-ELEGANS POU HOMEO BOX GENE CEH-18 CAUSE DEFECTS IN OOCYTE CELL-CYCLE ARREST, GONAD MIGRATION, AND EPIDERMAL DIFFERENTIATION [J].
GREENSTEIN, D ;
HIRD, S ;
PLASTERK, RHA ;
ANDACHI, Y ;
KOHARA, Y ;
WANG, B ;
FINNEY, M ;
RUVKUN, G .
GENES & DEVELOPMENT, 1994, 8 (16) :1935-1948
12345678910