The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways

被引：39

作者：

Abraham, RT ^{[1
]}

机构：

[1] Burnham Inst, Program Signal Transduct Res, La Jolla, CA 92130 USA

来源：

DNA REPAIR | 2004年 / 3卷 / 8-9期

关键词：

D O I：

10.1016/j.dnarep.2004.04.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent studies have identified, hSMG-1 as the newest member of the phosphomositide 3-kinase(PI3-kinase)-related kinase (PIKK) family. The protein kinase activity of hSMG-1 resembles that of the related PIKK, ATM, both in terms Of Substrate specificity and its sensitivity to inhibition by the fungal metabolite wortmannin. hSMG-1 is the ortholog of a Caenorhabditis elegans protein, CeSMG-1, which has been genetically linked to a critical mRNA surveillance pathway termed nonsense-mediated decay (NMD). The function of NMD is to mark for rapid degradation mRNAs that bear a premature termination codon. Compelling evidence now indicates that hSMG-1 is also a central player in the NMD pathway in human cells. In addition, hSMG-1, like ATM, appears to be involved in the recognition and/or repair of damaged DNA in these cells. In this review, we introduce a model in which hSMG-1 teams with ATM and ATR to insure the overall quality of the transcriptome in human cells. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：919 / 925

页数：7

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