Golgi Fragmentation in Neurodegenerative Diseases: Is There a Common Cause?

被引:53
作者
Angel Martinez-Menarguez, Jose [1 ]
Tomas, Monica [2 ]
Martinez-Martinez, Narcisa [1 ]
Martinez-Alonso, Emma [1 ]
机构
[1] Univ Murcia, Dept Cell Biol & Histol, Med Sch, Biomed Res Inst Murcia IMIB Arrixaca UMU, E-30100 Murcia, Spain
[2] Univ Valencia, Dept Human Anat & Embriol, Med Sch, Valencia 46010, Spain
关键词
Golgi complex; neurodegenerative diseases; intracellular transport; cytoskeleton; protein aggregates; AMYOTROPHIC-LATERAL-SCLEROSIS; CASPASE-MEDIATED CLEAVAGE; ALPHA-SYNUCLEIN TOXICITY; SPINAL MUSCULAR-ATROPHY; ANTERIOR HORN CELLS; ALZHEIMERS-DISEASE; MOTOR-NEURONS; ENDOPLASMIC-RETICULUM; PARKINSONS-DISEASE; MICROTUBULE NUCLEATION;
D O I
10.3390/cells8070748
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In most mammalian cells, the Golgi complex forms a continuous ribbon. In neurodegenerative diseases, the Golgi ribbon of a specific group of neurons is typically broken into isolated elements, a very early event which happens before clinical and other pathological symptoms become evident. It is not known whether this phenomenon is caused by mechanisms associated with cell death or if, conversely, it triggers apoptosis. When the phenomenon was studied in diseases such as Parkinson's and Alzheimer's or amyotrophic lateral sclerosis, it was attributed to a variety of causes, including the presence of cytoplasmatic protein aggregates, malfunctioning of intracellular traffic and/or alterations in the cytoskeleton. In the present review, we summarize the current findings related to these and other neurodegenerative diseases and try to search for clues on putative common causes.
引用
收藏
页数:19
相关论文
共 154 条
  • [41] Golgi bypass for local delivery of axonal proteins, fact or fiction?
    Gonzalez, Carolina
    Hugo Cornejo, Vitor
    Couve, Andres
    [J]. CURRENT OPINION IN CELL BIOLOGY, 2018, 53 : 9 - 14
  • [42] Golgi fragmentation occurs in the cells with prefibrillar α-synuclein aggregates and precedes the formation of fibrillar inclusion
    Gosavi, N
    Lee, HJ
    Lee, JS
    Patel, S
    Lee, SJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (50) : 48984 - 48992
  • [43] The Golgi ribbon in mammalian cells negatively regulates autophagy by modulating mTOR activity
    Gosavi, Prajakta
    Houghton, Fiona J.
    McMillan, Paul J.
    Hanssen, Eric
    Gleeson, Paul A.
    [J]. JOURNAL OF CELL SCIENCE, 2018, 131 (03)
  • [44] The Function of the Golgi Ribbon Structure - An Enduring Mystery Unfolds!
    Gosavi, Prajakta
    Gleeson, Paul A.
    [J]. BIOESSAYS, 2017, 39 (11)
  • [45] Goud Bruno, 2018, Small GTPases, V9, P66, DOI 10.1080/21541248.2017.1384087
  • [46] Connecting the Cytoskeleton to the Endoplasmic Reticulum and Golgi
    Gurel, Pinar S.
    Hatch, Anna L.
    Higgs, Henry N.
    [J]. CURRENT BIOLOGY, 2014, 24 (14) : R660 - R672
  • [47] Golgi Fragmentation in ALS Motor Neurons. New Mechanisms Targeting Microtubules, Tethers, and Transport Vesicles
    Haase, Georg
    Rabouille, Catherine
    [J]. FRONTIERS IN NEUROSCIENCE, 2015, 9
  • [48] Genetic classification of primary neurodegenerative disease
    Hardy, J
    Gwinn-Hardy, K
    [J]. SCIENCE, 1998, 282 (5391) : 1075 - 1079
  • [49] Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis
    Horton, AC
    Rácz, B
    Monson, EE
    Lin, AL
    Weinberg, RJ
    Ehlers, MD
    [J]. NEURON, 2005, 48 (05) : 757 - 771
  • [50] Horton AC, 2003, J NEUROSCI, V23, P6188