Gestation-induced changes in lamotrigine pharmacokinetics:: A monotherapy study

被引：136
作者：
de Haan, GJ
Edelbroek, P
Segers, J
Engelsman, M
Lindhout, D
Dévilé-Notschaele, M
Augustijn, P
机构：
[1] SEIN, Epilepsy Inst Netherlands, Dept Neurol & Epileptol, NL-2100 AA Heemstede, Netherlands
[2] SEIN, Epilepsy Inst Netherlands, Lab Clin Chem & Clin Pharmacol, NL-2100 AA Heemstede, Netherlands
[3] Univ Med Ctr, DBG Dept Med Genet, Utrecht, Netherlands
来源：
NEUROLOGY | 2004年 / 63卷 / 03期
关键词：
D O I：
10.1212/01.WNL.0000133213.10244.FD
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The authors describe 12 pregnancies in women with epilepsy using lamotrigine (LTG) monotherapy. A seizure increase in nine pregnancies was probably related to a gradual decline of LTG level-to-dose ratio to 40% of baseline. After delivery, LTG kinetics returned swiftly to baseline, causing toxic side effects in some women. Frequent LTG level monitoring and appropriate dose adjustments are advised in the period before and during pregnancy and after delivery, especially in women on LTG monotherapy.
引用
收藏
页码：571 / 573
页数：3
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