Inhibitory effects of compounds isolated from roots of Cynanchum wilfordii on oxidation and glycation of human low-density lipoprotein (LDL)

被引:11
作者
Kim, Jae-Yong [1 ]
Lee, Jung Woo [1 ]
Lee, Jin Soo [2 ]
Jang, Dae Sik [2 ]
Shim, Sang Hee [1 ]
机构
[1] Duksung Womens Univ, Coll Pharm, 144 Gil 33 Samyang Ro, Seoul 01369, South Korea
[2] Kyung Hee Univ, Grad Sch, Dept Life & Nanopharmaceut Sci, 26 Kyungheedae Ro, Seoul 02447, South Korea
基金
新加坡国家研究基金会; 芬兰科学院;
关键词
Cynanchum wilfordii; Phenolic compound; Pregnane-type steroids; Low-density lipoprotein (LDL); Oxidation; Glycation; C-21 STEROIDAL GLYCOSIDES; CHEMICAL-CONSTITUENTS; APOLIPOPROTEIN-B; ATHEROSCLEROSIS; IDENTIFICATION;
D O I
10.1016/j.jff.2019.05.045
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Low-density lipoprotein (LDL) modification such as oxidation and glycation has been known to play a significant role in the initiation and progression of atherosclerosis. The inhibitors on LDL modification have been emerged as a new strategy to be a supplement for prevention of atherosclerosis. In an effort to discover inhibitors on LDL modification from natural products, phytochemical investigation on Cynanchum wilfordii roots were performed, leading to isolation of acetophenones (1-6) including a new one (1) and nine pregnane-type steroids (7-15). The structure of the compound 1 was determined by analysis of 1D and 2D NMR spectral data analysis. All the isolated compounds were evaluated for their inhibitory activities against LDL modification. Among them, compounds 2 and 5 strongly inhibited LDL oxidation and glycation. These results suggest that compounds 2 and 5 from C. wilfordii may provide potential protective effects against atherosclerosis via inhibition of LDL oxidation and glycation.
引用
收藏
页码:281 / 290
页数:10
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