Are studies of motor cortex plasticity relevant in human patients with Parkinson's disease?

被引：31
作者：
Bologna, Matteo [1 ]
Suppa, Antonio [1 ]
Conte, Antonella [1 ]
Latorre, Anna [2 ]
Rothwell, John C. [3 ]
Berardelli, Alfredo [1 ,2 ]
机构：
[1] IRCCS, Neuromed Inst, Pozzilli, IS, Italy
[2] Univ Roma La Sapienza, Dept Neurol & Psychiat, I-00185 Rome, Italy
[3] UCL Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London, England
来源：
CLINICAL NEUROPHYSIOLOGY | 2016年 / 127卷 / 01期
关键词：
Parkinson's disease; Transcranial magnetic stimulation; Synaptic transmission and plasticity; Neurophysiology; TRANSCRANIAL MAGNETIC STIMULATION; THETA-BURST-STIMULATION; PAIRED ASSOCIATIVE STIMULATION; STRIATAL SYNAPTIC PLASTICITY; MULTIPLE SYSTEM ATROPHY; INTERVAL INTRACORTICAL INHIBITION; REPETITIVE CORTICAL STIMULATION; PROGRESSIVE SUPRANUCLEAR PALSY; NONINVASIVE BRAIN-STIMULATION; LEVODOPA-INDUCED DYSKINESIAS;
D O I：
10.1016/j.clinph.2015.02.009
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Over the last decade, electrophysiological studies in parkinsonian animals have shown that there are abnormalities of synaptic plasticity in motor areas of cortex and basal ganglia. In humans with Parkinson's disease (PD), cortical plasticity has been widely investigated using transcranial magnetic stimulation. A number of studies have reported abnormal responses to several different conditioning protocols, but their relationship to altered basal ganglia output and dopaminergic loss is still not entirely clear. Thus in the near future it seems unlikely that measures of cortical plasticity could be used as a biomarker of disease severity and progression. In this review we provide an overview on current knowledge of abnormalities of plasticity in PD in the light of recent advances in parkinsonian animal models. Finally we will discuss the relevance of abnormalities of plasticity in the clinical context of PD. (C) 2015 Published by Elsevier Ireland Ltd. on behalf of International Federation of Clinical Neurophysiology.
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收藏
页码：50 / 59
页数：10
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