Effects of sleeve gastrectomy on the composition and diurnal oscillation of gut microbiota related to the metabolic improvements

被引:18
作者
Shao, Yikai [1 ]
Shen, Qiwei [1 ]
Hua, Rong [1 ]
Evers, Simon S. [2 ]
He, Kai [1 ]
Yao, Qiyuan [1 ]
机构
[1] Fudan Univ, Ctr Obes & Metab Surg, Huashan Hosp, 12 Middle Wulumuqi Rd, Shanghai 200040, Peoples R China
[2] Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA
关键词
Sleeve gastrectomy; Gut microbiota; Obesity; BARIATRIC SURGERY; OBESITY; DIET; INTERVENTION;
D O I
10.1016/j.soard.2018.02.024
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background: Disruptions of the composition and diurnal oscillation of gut microbiota are involved in metabolic disorders. Objectives: To identify alterations in both the composition and diurnal oscillation of gut microbiota after high-fat diet (HFD) feeding and sleeve gastrectomy (SG) related to host metabolic status. Setting: University laboratories. Methods: Twenty-one 6-week-old male C57 BL/6 J mice were randomized on an HFD (n = 14) or normal chow (NC, n = 7). After 14 weeks of feeding, HFD-induced obese mice were randomized to receive either SG or sham surgery (n = 7 in each group). Fecal samples were collected every 6 hours over a 24-hour period at 14 weeks of NC or HFD feeding and subsequently 8 weeks after surgery. The composition and diurnal oscillation of gut microbiota were characterized using next-generation Illumina sequencing of 16 S rDNA. Results: HFD feeding led to adiposity, disrupted composition, and impaired diurnal oscillation of gut microbiota relative to NC. After surgery, SG mice had considerable weight loss, improved glucose tolerance, and insulin sensitivity compared with sham mice. SG restored the reduced richness and disruptions in the composition of gut microbiota. The diminished diurnal oscillation of gut microbiota was improved after SG. Conclusion: SG not only changed the disrupted composition of gut microbiota toward that of NC feeding, but also improved the dampened diurnal oscillation of gut microbiota due to HFD feeding. (C) 2018 American Society for Metabolic and Bariatric Surgery. All rights reserved.
引用
收藏
页码:731 / 739
页数:9
相关论文
共 28 条
  • [11] Time of day and eating behaviors are associated with the composition and function of the human gastrointestinal microbiota
    Kaczmarek, Jennifer L.
    Musaad, Salma M. A.
    Holscher, Hannah D.
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2017, 106 (05) : 1220 - 1231
  • [12] Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism
    Leone, Vanessa
    Gibbons, Sean M.
    Martinez, Kristina
    Hutchison, Alan L.
    Huang, Edmond Y.
    Cham, Candace M.
    Pierre, Joseph F.
    Heneghan, Aaron F.
    Nadimpalli, Anuradha
    Hubert, Nathaniel
    Zale, Elizabeth
    Wang, Yunwei
    Huang, Yong
    Theriault, Betty
    Dinner, Aaron R.
    Musch, Mark W.
    Kudsk, Kenneth A.
    Prendergast, Brian J.
    Gilbert, Jack A.
    Chang, Eugene B.
    [J]. CELL HOST & MICROBE, 2015, 17 (05) : 681 - 689
  • [13] Microbial ecology - Human gut microbes associated with obesity
    Ley, Ruth E.
    Turnbaugh, Peter J.
    Klein, Samuel
    Gordon, Jeffrey I.
    [J]. NATURE, 2006, 444 (7122) : 1022 - 1023
  • [14] Conserved Shifts in the Gut Microbiota Due to Gastric Bypass Reduce Host Weight and Adiposity
    Liou, Alice P.
    Paziuk, Melissa
    Luevano, Jesus-Mario, Jr.
    Machineni, Sriram
    Turnbaugh, Peter J.
    Kaplan, Lee M.
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (178)
  • [15] Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
    Liu, Ruixin
    Hong, Jie
    Xu, Xiaoqiang
    Feng, Qiang
    Zhang, Dongya
    Gu, Yanyun
    Shi, Juan
    Zhao, Shaoqian
    Liu, Wen
    Wang, Xiaokai
    Xia, Huihua
    Liu, Zhipeng
    Cui, Bin
    Liang, Peiwen
    Xi, Liuqing
    Jin, Jiabin
    Ying, Xiayang
    Wang, Xiaolin
    Zhao, Xinjie
    Li, Wanyu
    Jia, Huijue
    Lan, Zhou
    Li, Fengyu
    Wang, Rui
    Sun, Yingkai
    Yang, Minglan
    Shen, Yuxin
    Jie, Zhuye
    Li, Junhua
    Chen, Xiaomin
    Zhong, Huanzi
    Xie, Hailiang
    Zhang, Yifei
    Gu, Weiqiong
    Deng, Xiaxing
    Shen, Baiyong
    Xu, Xun
    Yang, Huanming
    Xu, Guowang
    Bi, Yufang
    Lai, Shenghan
    Wang, Jian
    Qi, Lu
    Madsen, Lise
    Wang, Jiqiu
    Ning, Guang
    Kristiansen, Karsten
    Wang, Weiqing
    [J]. NATURE MEDICINE, 2017, 23 (07) : 859 - +
  • [16] Quantitative and qualitative β diversity measures lead to different insights into factors that structure microbial communities
    Lozupone, Catherine A.
    Hamady, Micah
    Kelley, Scott T.
    Knight, Rob
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2007, 73 (05) : 1576 - 1585
  • [17] Multivariate analyses in microbial ecology
    Ramette, Alban
    [J]. FEMS MICROBIOLOGY ECOLOGY, 2007, 62 (02) : 142 - 160
  • [18] Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
    Ridaura, Vanessa K.
    Faith, Jeremiah J.
    Rey, Federico E.
    Cheng, Jiye
    Duncan, Alexis E.
    Kau, Andrew L.
    Griffin, Nicholas W.
    Lombard, Vincent
    Henrissat, Bernard
    Bain, James R.
    Muehlbauer, Michael J.
    Ilkayeva, Olga
    Semenkovich, Clay F.
    Funai, Katsuhiko
    Hayashi, David K.
    Lyle, Barbara J.
    Martini, Margaret C.
    Ursell, Luke K.
    Clemente, Jose C.
    Van Treuren, William
    Walters, William A.
    Knight, Rob
    Newgard, Christopher B.
    Heath, Andrew C.
    Gordon, Jeffrey I.
    [J]. SCIENCE, 2013, 341 (6150) : 1079 - U49
  • [19] FXR is a molecular target for the effects of vertical sleeve gastrectomy
    Ryan, Karen K.
    Tremaroli, Valentina
    Clemmensen, Christoffer
    Kovatcheva-Datchary, Petia
    Myronovych, Andriy
    Karns, Rebekah
    Wilson-Perez, Hilary E.
    Sandoval, Darleen A.
    Kohli, Rohit
    Backhed, Fredrik
    Seeley, Randy J.
    [J]. NATURE, 2014, 509 (7499) : 183 - +
  • [20] Bariatric Surgery versus Intensive Medical Therapy for Diabetes-5-Year Outcomes
    Schauer, Philip R.
    Bhatt, Deepak L.
    Kirwan, John P.
    Wolski, Kathy
    Aminian, Ali
    Brethauer, Stacy A.
    Navaneethan, Sankar D.
    Singh, Rishi P.
    Pothier, Claire E.
    Nissen, Steven E.
    Kashyap, Sangeeta R.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (07) : 641 - 651