Targeted Pituitary Adenylate Cyclase-Activating Peptide Therapies for Migraine

被引：36
作者：
Vollesen, Anne Luise Haulund [1 ,2 ]
Amin, Faisal Mohammad [1 ,2 ]
Ashina, Messoud [1 ,2 ]
机构：
[1] Univ Copenhagen, Fac Hlth & Med Sci, Rigshosp Glostrup, Danish Headache Ctr, DK-2600 Copenhagen, Denmark
[2] Univ Copenhagen, Fac Hlth & Med Sci, Rigshosp Glostrup, Dept Neurol, DK-2600 Copenhagen, Denmark
来源：
NEUROTHERAPEUTICS | 2018年 / 15卷 / 02期
关键词：
PACAP38; PAC(1) receptor; Vasoactive intestinal polypeptide; Human provocation models; Primary headaches; Migraine; VASOACTIVE INTESTINAL POLYPEPTIDE; MIDDLE MENINGEAL ARTERY; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; CENTRAL-NERVOUS-SYSTEM; IN-SITU HYBRIDIZATION; MESSENGER-RNA; RAT-BRAIN; PACAP RECEPTORS; GENE-EXPRESSION; DOUBLE-BLIND;
D O I：
10.1007/s13311-017-0596-x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Here, we review the role of pituitary adenylate cyclase-activating peptide-38 (PACAP38) in migraine pathophysiology and data implicating PAC(1) receptor as a future drug target in migraine. Much remains to be fully elucidated about migraine pathophysiology, but recent attention has focused on signaling molecule PACAP38, a vasodilator able to induce migraine attacks in patients who experience migraine without aura. PACAP38, with marked and sustained effect, dilates extracerebral arteries but not the middle cerebral artery. The selective affinity of PACAP38 to the PAC(1) receptor makes this receptor a highly interesting and potential novel target for migraine treatment. Efficacy of antagonism of this receptor should be investigated in randomized clinical trials.
引用
收藏
页码：371 / 376
页数：6
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