Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

被引:156
作者
Gilmore, TD [1 ]
机构
[1] Boston Univ, Dept Biol, Boston, MA 02215 USA
关键词
v-Rel; Rel; NF-kappa B; malignant transformation; transcription factor; retroviral oncogene;
D O I
10.1038/sj.onc.1203222
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The avian Rev-T retrovirus encodes the v-Rel oncoprotein, which is a member of the Rel/NF-kappa B transcription factor family. v-Rel induces a rapidly fatal lymphoma/leukemia in young birds, and v-Rel can transform and immortalize a variety of avian cell types irt vitro. Although Rel/NF-kappa B transcription factors have been associated with oncogenesis in mammals, v-Rel is the only member of this family that is frankly oncogenic in animal model systems. The potent oncogenicity of v-Rel is the consequence of a number of mutations that have altered its activity and regulation: for example, certain mutations decrease its ability to be regulated by I kappa B alpha, change its DNA-binding site specificity, and endow it with new transactivation properties. The study of v-Rel will continue to increase our knowledge of how cellular Rel proteins contribute to oncogenesis by affecting cell growth, altering cell-cycle regulation, and blocking apoptosis, This review will discuss biological and molecular activities of v-Rel, with particular attention to how these activities relate to structure-function aspects of the Rel/NF-kappa B transcription factors.
引用
收藏
页码:6925 / 6937
页数:13
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