Cross-Linked Carboxybetaine SAMs Enable Nanoparticles with Remarkable Stability in Complex Media

被引：15

作者：

Yang, Wei ^{[1
]}

Ella-Menye, Jean-Rene ^{[1
]}

Liu, Sijun ^{[2
]}

Bai, Tao ^{[1
]}

Wang, Daqian ^{[1
]}

Yu, Qiuming ^{[1
]}

Li, Yuting ^{[1
]}

Jiang, Shaoyi ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA

[2] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

LANGMUIR | 2014年 / 30卷 / 09期

基金：

美国国家科学基金会;

关键词：

SELF-ASSEMBLED MONOLAYERS; GOLD NANOPARTICLES; ZWITTERIONIC POLYMER; DIACETYLENE; PHOTOPOLYMERIZATION; POLY(CARBOXYBETAINE); DERIVATIVES; ADSORPTION; SURFACES; GLYCOL);

D O I：

10.1021/la404941m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A photo-cross-linkable carboxybetaine (CB)-terminated thiol with only one CB headgroup was introduced to modify gold nanoparticles (GNPs) via self-assembled monolayers (SAMs). This CB-terminated thiol consists of three moieties: (a) an anchoring thiol group, which binds directly to the GNP surface, (b) a CB terminal group, which is highly resistant to protein adsorption, and (c) a diacetylene group in the middle, which is converted to a poly(enyne) structure during UV irradiation via 1,4-topochemical polymerization. Results show that, after cross-linking, CB-modified GNPs are highly resistant to protein adsorption from undiluted human blood serum and cell uptake, and are stable at low pH and high temperature. This cross-linkable CB thiol holds tremendous potentials for biomedical applications where stable and thin coatings are needed.

引用

页码：2522 / 2529

页数：8

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