Autophagy and Heart Disease: Implications for Cardiac Ischemia-Reperfusion Damage

被引：49

作者：

Ghavami, S. ^{[1
,2
,3
,4
]}

Gupta, S. ^{[1
,2
]}

Ambrose, E. ^{[1
,2
]}

Hnatowich, M. ^{[1
,2
]}

Freed, D. H. ^{[1
,2
]}

Dixon, I. M. C. ^{[1
,2
]}

机构：

[1] Univ Manitoba, Fac Med, Dept Physiol & Pathophysiol, Winnipeg, MB R3T 2N2, Canada

[2] Inst Cardiovasc Sci, St Boniface Res Ctr, Mol Cardiol Lab, Winnipeg, MB R2H 2A6, Canada

[3] Univ Manitoba, Manitoba Inst Child Hlth, Winnipeg, MB, Canada

[4] Univ Manitoba, Dept Human Anat & Cell Sci, Winnipeg, MB, Canada

来源：

CURRENT MOLECULAR MEDICINE | 2014年 / 14卷 / 05期

关键词：

Autophagy; heart; heart disease; ischemia-reperfusion; mitophagy; ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; HYPOXIA-INDUCIBLE FACTOR-1; PARKIN-MEDIATED MITOPHAGY; BETA-CELL MASS; PRESSURE-OVERLOAD; CROSS-TALK; STRESS; APOPTOSIS; DEATH;

D O I：

10.2174/1566524014666140603101520

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Survival of myocytes and mesenchymal cells in the heart is tightly regulated by a number of adaptive processes that are invoked with the changes that occur within the parenchyma and stroma. Autophagy is implicated in cellular housekeeping duties and maintenance of the integrity of the intracellular milieu by removal of protein aggregates and damaged organelles, whereas under pathophysiological conditions, the chronic up-regulation of autophagy may lead to significant disturbance of homeostatic conditions. Nonetheless, the role of autophagy in heart disease in the context of cardiac ischemia-reperfusion injury is currently unclear. This review will focus upon the role of autophagy as it pertains to ischemia-reperfusion damage in the heart.

引用

页码：616 / 629

页数：14

共 120 条

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