MYBL2 Is Targeted by miR-143-3p and Regulates Breast Cancer Cell Proliferation and Apoptosis

被引：55

作者：

Chen, Jianli ^{[1
]}

Chen, Xiaowen ^{[2
]}

机构：

[1] Xinxiang Med Univ, Affiliated Hosp 3, Dept Med Oncol 3, Xinxiang, Henan, Peoples R China

[2] Guangdong Med Coll, Affiliated Hosp, Dept Oncol Ctr, 57 South Peoples Ave, Zhanjiang 524000, Guangdong, Peoples R China

来源：

ONCOLOGY RESEARCH | 2018年 / 26卷 / 06期

关键词：

MYB proto-oncogene like 2 (MYBL2); Breast cancer; miR-143-3p; Cell apoptosis; Cell proliferation; INTERVENTION; METHYLATION; SUPPRESSES; INVASION; RISK;

D O I：

10.3727/096504017X15135941182107

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer remains a public health issue on a global scale. The present study aimed to explore the functional role of MYB proto-oncogene like 2 (MYBL2) in breast cancer, as well as underlying mechanisms. The regulatory relationship between miR-143-3p and MYBL2 was analyzed, and the effects of dysregulation of miR-143-3p and MYBL2 on cell proliferation and apoptosis were investigated. The results showed that MYBL2 and miR-143-3p were inversely expressed in breast cancer tissues and cells: MYBL2 was highly expressed, whereas miR-143-3p was lowly expressed. MYBL2 was confirmed as a target gene of miR-143-3p. Suppression of MYBL2 inhibited proliferation and induced apoptosis of breast cancer cells, which was similar to the effects of overexpression of miR-143-3p. Our findings reveal that MYBL2 is targeted by miR-143-3p and regulates breast cancer cell proliferation and apoptosis.

引用

页码：913 / 922

页数：10

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