Structural organization of DMPC lipid layers on chemically micropatterned self-assembled monolayers as biomimetic systems

被引：9

作者：

Brechling, A ^{[1
]}

Pohl, M ^{[1
]}

Kleineberg, U ^{[1
]}

Heinzmann, U ^{[1
]}

机构：

[1] Univ Bielefeld, Fac Phys, D-33501 Bielefeld, Germany

来源：

JOURNAL OF BIOTECHNOLOGY | 2004年 / 112卷 / 1-2期

关键词：

DMPC; X-ray reflectometry; self-assembled monolayers;

D O I：

10.1016/j.jbiotec.2004.04.022

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The growth structure of DMPC lipid layers on hydrophobic and hydrophilic alkylsilane-based self-assembled monolayers adsorbed on silicon has been investigated by means of X-ray reflectometry and atomic force microscopy. Hydrophilic modification of hydrophobically terminated ODS-SAMs has been achieved by dose-controlled irradiation with DUV light. While island formation of small DMPC bilayer islands is observed on hydrophobic SAM surfaces, closed layers of DMPC monolayers are formed on hydrophilic SAM surfaces. Furthermore, DMPC adsorption on chemically micropatterned substrates with alternating hydrophobic/hydrophilic surface properties has been studied by imaging ellipsometry and photoemission microscopy. Indication for at least partial bridging of hydrophobic areas by an adsorbed DMPC monolayer has been found. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：115 / 125

页数：11

共 24 条

[1] DEEP UV PHOTOCHEMISTRY OF CHEMISORBED MONOLAYERS - PATTERNED COPLANAR MOLECULAR ASSEMBLIES [J].