Cardiac inositol 1,4,5-trisphosphate receptors

被引：39

作者：

Garcia, M. Iveth ^{[1
,2
]}

Boehning, Darren ^{[2
]}

机构：

[1] Univ Texas Med Branch, Cell Biol Grad Program, Galveston, TX 77555 USA

[2] McGovern Med Sch UTHlth, Dept Biochem & Mol Biol, 6431 Fannin St,Suite 6-161, Houston, TX 77030 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2017年 / 1864卷 / 06期

关键词：

IP3; Receptor; Cardiac hypertrophy; Calcium channels; CA2+ RELEASE CHANNELS; IP3; RECEPTOR; CALCIUM-RELEASE; TRISPHOSPHATE RECEPTORS; FUNCTIONAL-CHARACTERIZATION; SPINOCEREBELLAR ATAXIA; VENTRICULAR MYOCYTES; HEART-FAILURE; DIFFERENTIAL REGULATION; DILATED CARDIOMYOPATHY;

D O I：

10.1016/j.bbamcr.2016.11.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcium is a second messenger that regulates almost all cellular functions. In cardiomyocytes, calcium plays an integral role in many functions including muscle contraction, gene expression, and cell death. Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are a family of calcium channels that are ubiquitously expressed in all tissues. In the heart, IP(3)Rs have been associated with regulation of cardiomyocyte function in response to a variety of neurohormonal agonists, including those implicated in cardiac disease. Notably, IP3R activity is thought to be essential for mediating the hypertrophic response to multiple stimuli including endothelin-1 and angiotensin II. In this review, we will explore the functional implications of IP3R activity in the heart in health and disease. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：907 / 914

页数：8

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