Tenofovir primes rhesus macaque cells in vitro for enhanced interleukin-12 secretion

被引：10
作者：
Van Rompay, KKA [1 ]
Marthas, ML
Bischofberger, N
机构：
[1] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA
[2] Gilead Sci Inc, Foster City, CA 94404 USA
来源：
ANTIVIRAL RESEARCH | 2004年 / 63卷 / 02期
关键词：
tenofovir; in vitro; IL-12; macaque; PMPA;
D O I：
10.1016/j.antiviral.2004.04.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We investigated if the antiviral drug tenofovir has immunomodulatory effects in macaques, similar to those described in murine models. While in vivo experiments were complicated by high individual and temporal variability of immune parameters, tenofovir primed macaque peripheral blood mononuclear cells in vitro for enhanced IL-12 secretion following exposure to bacterial antigens. (C) 2004 Elsevier B.V. All rights reserved.
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收藏
页码：133 / 138
页数：6
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