Fasicularin, a novel tricyclic alkaloid from the ascidian Nephteis fasicularis with selective activity against a DNA repair-deficient organism

被引：105
作者：
Patil, AD
Freyer, AJ
Reichwein, R
Carte, B
Killmer, LB
Faucette, L
Johnson, RK
Faulkner, DJ
机构：
[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT ANALYT SCI,RES & DEV,KING OF PRUSSIA,PA 19406
[2] UNIV CALIF SAN DIEGO,SCRIPPS INST OCEANOG,LA JOLLA,CA 92093
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 03期
关键词：
D O I：
10.1016/S0040-4039(96)02304-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel tricyclic alkaloid, fasicularin (1), was isolated from the Micronesian ascidian Nephteis fasicularis. The structure of I was elucidated primarily by interpretation of spectral data. Fasicularin was found to be active in a DNA damaging assay. Copyright (C) 1996 Elsevier Science Ltd
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页码：363 / 364
页数：2
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