Tuberculous meningitis: a roadmap for advancing basic and translational research

被引：39
作者：
Jain, Sanjay K. [1 ,2 ,3 ]
Tobin, David M. [4 ,5 ]
Tucker, Elizabeth W. [1 ,2 ,6 ]
Venketaraman, Vishwanath [7 ]
Ordonez, Alvaro A. [1 ,2 ,3 ]
Jayashankar, Lakshmi [8 ]
Siddiqi, Omar K. [9 ,10 ]
Hammoud, Dima A. [11 ]
Prasadarao, Nemani V. [12 ]
Sandor, Matyas [13 ]
Hafner, Richard [14 ]
Fabry, Zsuzsanna [13 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Ctr TB Res, Baltimore, MD 21218 USA
[2] Johns Hopkins Univ, Sch Med, Ctr Infect & Inflammat Imaging Res, Baltimore, MD 21218 USA
[3] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA
[4] Duke Univ, Sch Med, Dept Mol Genet, Durham, NC USA
[5] Duke Univ, Sch Med, Dept Microbiol & Immunol, Durham, NC USA
[6] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA
[7] Western Univ Hlth Sci, Dept Basic Med Sci, Pomona, CA USA
[8] Columbus Technol Inc, NIAID, US Natl Inst Hlth, Bethesda, MD USA
[9] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Global Neurol Program,Dept Neurol,Div Neuroimmuno, Boston, MA USA
[10] Univ Zambia, Sch Med, Dept Internal Med, Lusaka, Zambia
[11] NIAID, Ctr Infect Dis Imaging, 9000 Rockville Pike, Bethesda, MD 20892 USA
[12] Childrens Hosp Los Angeles, Sabin Res Inst, Los Angeles, CA 90027 USA
[13] Univ Wisconsin, Madison Sch Med & Publ Hlth, Dept Pathol & Lab Med, Madison, WI 53706 USA
[14] NIAID, Div Aids, 9000 Rockville Pike, Bethesda, MD 20892 USA
来源：
NATURE IMMUNOLOGY | 2018年 / 19卷 / 06期
关键词：
BRAIN; GENOTYPE; THERAPY; ADULTS;
D O I：
10.1038/s41590-018-0119-x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tuberculous meningitis is a serious, life-threatening disease affecting vulnerable populations, including HIV-infected individuals and young children. The US National Institutes of Health convened a workshop to identify knowledge gaps in the molecular and immunopathogenic mechanisms of tuberculous meningitis and to develop a roadmap for basic and translational research that could guide clinical studies.
引用
收藏
页码：521 / 525
页数：5
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