Osteoimmunology: The correlation between osteoclasts and the Th17/Treg balance in osteoporosis

被引：43

作者：

Huang, Fei ^{[1
]}

Wong, Puiian ^{[1
]}

Li, Jinglan ^{[2
]}

Lv, Zheng ^{[2
]}

Xu, Liangliang ^{[3
]}

Zhu, Genfu ^{[4
]}

He, Mincong ^{[5
]}

Luo, Yiwen ^{[1
]}

机构：

[1] Guangzhou Univ Chinese Med, Affiliated Hosp 3, Dept Traumatol, Guangzhou 510000, Guangdong, Peoples R China

[2] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Orthoped, Guangzhou, Peoples R China

[3] Guangzhou Univ Chinese Med, Lingnan Med Res Ctr, Lab Orthopaed & Traumatol, Guangzhou, Peoples R China

[4] Guangzhou Univ Chinese Med, Affiliated Hosp 3, Inst Osteoporosis, Guangzhou 510000, Guangdong, Peoples R China

[5] Guangzhou Univ Chinese Med, Guangdong Res Inst Orthoped & Traumatol Chinese M, Affiliated Hosp 3, Guangzhou 510000, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2022年 / 26卷 / 13期

关键词：

osteoimmunology; Th17; Treg; RANKL; osteoclasts; osteoporosis; DENDRITIC CELLS; IMMUNE-SYSTEM; BONE-MARROW; TREG CELLS; ARTHRITIS; RECEPTOR; LIGAND; MACROPHAGES; SUPPRESSION; PREVENTION;

D O I：

10.1111/jcmm.17399

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Osteoporosis is a bone disease that is caused by disorder of the skeletal microenvironment, and it characterized by a high disability rate and the occurrence of low energy fractures. Studies on osteoporosis and related treatment options have always been hot spots in the field of bone biology. In the past, the understanding of osteoporosis has been rather limited; research has only shown that osteoporosis involves the imbalance of bone resorption and bone formation, and recent studies have not provided cutting-edge theories of the basic understanding of osteoporosis. Recent studies have shown crosstalk between bone and immune responses. RANKL, an essential factor for osteoclasts (OCs), is associated with the immune system. T helper (Th17)/regulatory T (Treg) cells are two different kinds of T cells that can self-interact and regulate the differentiation and formation of OCs. Therefore, understanding the correlation between the skeletal and immune systems and further revealing the roles and the cooperation between RANKL and the Th17/Treg balance will help to provide new insights for the treatment of osteoporosis.

引用

页码：3591 / 3597

页数：7

共 46 条

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