Dexamethasone in Cryptococcus gattii Central Nervous System Infection

被引：37
作者：
Phillips, Peter [1 ,5 ]
Chapman, Kristine [2 ,5 ]
Sharp, Madeleine [2 ]
Harrison, Phil [3 ,5 ]
Vortel, Jerry [6 ]
Steiner, Theodore [4 ,5 ]
Bowie, William [4 ,5 ]
机构：
[1] St Pauls Hosp, Div Infect Dis, Vancouver, BC V6Z 1Y6, Canada
[2] St Pauls Hosp, Div Neurol, Vancouver, BC V6Z 1Y6, Canada
[3] St Pauls Hosp, Dept Radiol, Vancouver, BC V6Z 1Y6, Canada
[4] Vancouver Gen Hosp, Div Infect Dis, Vancouver, BC, Canada
[5] Univ British Columbia, Dept Med, Vancouver, BC, Canada
[6] Richmond Gen Hosp, Div Infect Dis, Richmond, BC, Canada
来源：
CLINICAL INFECTIOUS DISEASES | 2009年 / 49卷 / 04期
关键词：
ENDOTHELIAL GROWTH-FACTOR; NEOFORMANS; VARIETY; MANAGEMENT; DISEASE; AIDS;
D O I：
10.1086/603554
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Clinical outcomes were reviewed for 4 patients with Cryptococcus gattii central nervous system infection who received dexamethasone for the treatment of persisting mental status abnormalities and focal lesions on brain scan despite culture-negative cerebrospinal fluid and the management of intracranial pressure. Favorable clinical responses were observed in 3 patients. Although corticosteroids are not recommended for the treatment of cryptococcal meningitis, these observations suggest that dexamethasone should be further evaluated in this subset of patients.
引用
收藏
页码：591 / 595
页数：5
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