Parallels and distinctions between T and NKT cell development in the thymus

被引：39
|
作者：
Berzins, SP [1 ]
Uldrich, AP
Pellicci, DG
McNab, F
Hayakawa, Y
Smyth, MJ
Godfrey, DI
机构：
[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia
[2] Peter MacCallum Canc Ctr, Trescowthick Labs, Canc Immunol Program, Melbourne, Vic 3002, Australia
[3] Monash Univ, Cent & Eastern Clin Sch, Dept Immunol, Prahran, Vic 3181, Australia
来源：
IMMUNOLOGY AND CELL BIOLOGY | 2004年 / 82卷 / 03期
关键词：
CD1d; development; NK1.1; NKT cells; thymus;
D O I：
10.1111/j.0818-9641.2004.01256.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
NKT cells are emerging as an extremely influential regulatory subset of T lymphocytes that are functionally and developmentally distinct from their mainstream counterparts. Like other T cells, NKT cells are thymus-dependent but their apparently unique pathway of differentiation is poorly characterized. Given the strong association between NKT cell deficiency and increased incidences of autoimmunity and cancer it is imperative that the mechanisms by which NKT cells are generated becomes better understood. This review examines what is known about NKT cell development in the thymus and highlights elements of the pathway that differ significantly from mainstream T-cell development. It is here that NKT cell-specific disorders may originate and may best be addressed.
引用
收藏
页码：269 / 275
页数：7
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