Complete Response of Adult-Onset CNS Langerhans Cell Histiocytosis Documented on 18F-FDG PET/CT

被引：7

作者：

Kruljac, Ivan ^{[1
]}

Balenovic, Antonija ^{[2
]}

Gacina, Petar ^{[3
]}

Imashuku, Shinsaku ^{[4
]}

Vrkljan, Milan ^{[1
]}

机构：

[1] Univ Zagreb, Univ Hosp Ctr Sestre Milosrdnice, Dept Endocrinol Diabet & Metab Dis Mladen Sekso, Sch Med, Zagreb 10000, Croatia

[2] Medikol Clin, Dept Nucl Med, Zagreb, Croatia

[3] Takasago Seibu Hosp, Div Pediat, Takasago, Hyogo, Japan

[4] Univ Hosp Ctr Sestre Milosrdnice, Dept Hematol, Zagreb, Croatia

来源：

CLINICAL NUCLEAR MEDICINE | 2015年 / 40卷 / 12期

关键词：

F-18-FDG PET; CT; Langerhans cell histiocytosis; chemotherapy; vinblastine; remission; response; TOMOGRAPHY; MANAGEMENT; THERAPY;

D O I：

10.1097/RLU.0000000000000994

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We report a case of a 49-year-old woman with biopsy-proven multisystemic Langerhans cell histiocytosis (LCH) with hypothalamic involvement documented on F-18-FDG PET/CT. Chemotherapy with a combination of vinblastine, prednisolone, methotrexate, and 6-mercaptopurine was carried out. Two months later, a 90% reduction of the hypothalamic tumor mass was noted on magnetic resonance imaging, but with no signs of pathological F-18-FDG accumulation. The patient died 4 months later, and we found no signs of LCH on autopsy. Our case highlights the need for further studies regarding the role of F-18-FDG PET/CT in the assessment of treatment response in patients with LCH.

引用

页码：981 / 982

页数：2

共 8 条

[1] 18F-Fluorodeoxyglucose-Positron Emission Tomography Scanning Is More Useful in Followup Than in the Initial Assessment of Patients With Erdheim-Chester Disease [J].

Arnaud, Laurent ;

Malek, Zoulikha ;

Archambaud, Frederique ;

Kas, Aurelie ;

Toledano, Dan ;

Drier, Aurelie ;

Zeitoun, Delphine ;

Cluzel, Philippe ;

Grenier, Philippe A. ;

Chiras, Jacques ;

Piette, Jean-Charles ;

Amoura, Zahir ;

Haroche, Julien .

ARTHRITIS AND RHEUMATISM, 2009, 60 (10) :3128-3138

[2] Current therapy for Langerhans cell histiocytosis [J].

Broadbent, V ;

Gadner, H .

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 1998, 12 (02) :327-+

[3] Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis [J].

Gadner, Helmut ;

Minkov, Milen ;

Grois, Nicole ;

Poetschger, Ulrike ;

Thiem, Elfriede ;

Arico, Maurizio ;

Astigarraga, Itziar ;

Braier, Jorge ;

Donadieu, Jean ;

Henter, Jan-Inge ;

Janka-Schaub, Gritta ;

McClain, Kenneth L. ;

Weitzman, Sheila ;

Windebank, Kevin ;

Ladisch, Stephan .

BLOOD, 2013, 121 (25) :5006-5014

[4] Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net [J].

Girschikofsky, Michael ;

Arico, Maurizio ;

Castillo, Diego ;

Chu, Anthony ;

Doberauer, Claus ;

Fichter, Joachim ;

Haroche, Julien ;

Kaltsas, Gregory A. ;

Makras, Polyzois ;

Marzano, Angelo V. ;

de Menthon, Mathilde ;

Micke, Oliver ;

Passoni, Emanuela ;

Seegenschmiedt, Heinrich M. ;

Tazi, Abdellatif ;

McClain, Kenneth L. .

ORPHANET JOURNAL OF RARE DISEASES, 2013, 8

[5] Treatment of patients with hypothalamic-pituitary lesions as adult-onset Langerhans cell histiocytosis [J].

Imashuku, Shinsaku ;

Kudo, Naoko ;

Kaneda, Shigehiro ;

Kuroda, Hiroshi ;

Shiwa, Tsuguka ;

Hiraiwa, Tetsuya ;

Inagaki, Atsushi ;

Morimoto, Akira .

INTERNATIONAL JOURNAL OF HEMATOLOGY, 2011, 94 (06) :556-560

[6] Response of Histiocytoses to Imatinib Mesylate: Fire to Ashes [J].

Janku, Filip ;

Amin, Hesham M. ;

Yang, Dan ;

Garrido-Laguna, Ignacio ;

Trent, Jonathan C. ;

Kurzrock, Razelle .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (31) :E633-E636

[7] The usefulness of F-18 fluorodeoxyglucose positron emission tomography/computed tomography in patients with Langerhans cell histiocytosis [J].

Lee, Hong Je ;

Ahn, Byeong-Cheol ;

Lee, Sang-Woo ;

Lee, Jaetae .

ANNALS OF NUCLEAR MEDICINE, 2012, 26 (09) :730-737

[8] Comparison of FDG-PET Scans to Conventional Radiography and Bone Scans in Management of Langerhans Cell Histiocytosis [J].

Phillips, Michelle ;

Allen, Carl ;

Gerson, Paul ;

McClain, Kenneth .

PEDIATRIC BLOOD & CANCER, 2009, 52 (01) :97-101

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