Tandem C-2 Functionalization-Intramolecular Azide-Alkyne 1,3-Dipolar Cycloaddition Reaction: A Convenient Route to Highly Diversified 9H-Benzo[b]pyrrolo[1,2-g][1,2,3]triazolo[1,5-d[1,4]diazepines

被引：48

作者：

Hussain, Mohd Kamil ^{[1
]}

Ansari, Mohd Imran ^{[1
]}

Kant, Ruchir ^{[2
]}

Hajela, Kanchan ^{[1
]}

机构：

[1] Cent Drug Res Inst, CSIR, Med & Proc Chem Div, Lucknow 226031, Uttar Pradesh, India

[2] Cent Drug Res Inst, CSIR, Mol & Struct Biol Div, Lucknow 226031, Uttar Pradesh, India

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 02期

关键词：

C BOND FORMATION; CASCADE REACTIONS; EFFICIENT SYNTHESIS; N-ARYLATION; PHASE-I; ONE-POT; N-(2-HALOARYL)PROPIOLAMIDES; PROPARGYLATION; INHIBITOR; RECEPTORS;

D O I：

10.1021/ol403420z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient diversity-oriented synthetic approach to annulated 9H-benzo[b]pyrrolo[1,2-g][1,2,3]triazolo[1,5-d][1,4]diazepines has been developed using a R Sc(OTf)(3)-catalyzed two-component tandem C-2 functionalization intramolecular azide-alkyne 1,3-dipolar cycloaddition reaction. The reaction shows high substrate tolerance and provides a library of fused heterocycles that may. lead to novel biologically active compounds or drug lead molecules.

引用

页码：560 / 563

页数：4

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