Evaluating the role of mitochondrial DNA variation to the genetic predisposition to radiation-induced toxicity

被引：10

作者：

Fachal, Laura ^{[1
]}

Mosquera-Miguel, Ana ^{[2
,3
]}

Gomez-Caamano, Antonio ^{[4
]}

Sanchez-Garcia, Manuel ^{[5
]}

Calvo, Patricia ^{[4
]}

Lobato-Busto, Ramon ^{[5
]}

Salas, Antonio ^{[2
,3
]}

Vega, Ana ^{[1
]}

机构：

[1] Fdn Publ Galega Med Xen SERGAS, Grp Med Xen, CIBERER, IDIS, Santiago De Compostela, Spain

[2] Univ Santiago de Compostela, Fac Med, Inst Ciencias Forenses, Unidade Xenet, Galicia, Spain

[3] Univ Santiago de Compostela, Fac Med, Dept Anat Patol & Ciencias Forenses, Galicia, Spain

[4] Complexo Hosp Univ Santiago, SERGAS, Dept Radiat Oncol, Santiago De Compostela, Spain

[5] Complex Hosp Univ Santiago, SERGAS, Dept Med Phys, Santiago De Compostela, Spain

来源：

RADIOTHERAPY AND ONCOLOGY | 2014年 / 111卷 / 02期

关键词：

Prostate cancer; 3D-CRT; SNP; mtDNA; PROSTATE-CANCER PATIENTS; HAPLOGROUPS; RISK; APOPTOSIS; SEQUENCE; DISEASE; GENOME;

D O I：

10.1016/j.radonc.2014.03.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and purpose: Mitochondrial DNA common variants have been reported to be associated with the development of radiation-induced toxicity. Using a large cohort of patients, we aimed to validate these findings by investigating the potential role of common European mitochondrial DNA SNPs (mtSNPs) to the development of radio-toxicity. Material and methods: Overall acute and late toxicity data were assessed in a cohort of 606 prostate cancer patients by means of Standardized Total Average Toxicity (STAT) score. We carried out association tests between radiation toxicity and a selection of 15 mtSNPs (and the haplogroups defined by them). Results: Statistically significant association between mtSNPs and haplogroups with toxicity could not be validated in our Spanish cohort. Conclusions: The present study suggests that the mtDNA common variants analyzed are not associated with clinically relevant increases in risk of overall radiation-induced toxicity in prostate cancer patients. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：199 / 205

页数：7

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