Plasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

被引：47

作者：

Nitter, M. ^{[1
]}

Norgard, B. ^{[1
]}

de Vogel, S. ^{[1
]}

Eussen, S. J. P. M. ^{[1
,2
,3
]}

Meyer, K. ^{[4
]}

Ulvik, A. ^{[4
]}

Ueland, P. M. ^{[2
,5
]}

Nygard, O. ^{[6
,7
]}

Vollset, S. E. ^{[1
,8
]}

Bjorge, T. ^{[1
,8
]}

Tjonneland, A. ^{[9
]}

Hansen, L. ^{[9
]}

Boutron-Ruault, M. ^{[10
,11
,12
]}

Racine, A. ^{[10
,11
,12
]}

Cottet, V. ^{[13
]}

Kaaks, R. ^{[14
]}

Kuehn, T. ^{[14
]}

Trichopoulou, A. ^{[15
,16
]}

Bamia, C. ^{[15
,16
]}

Naska, A. ^{[15
,16
]}

Grioni, S. ^{[17
]}

Palli, D. ^{[18
]}

Panico, S. ^{[19
]}

Tumino, R. ^{[20
]}

Vineis, P. ^{[21
,22
,23
]}

Bueno-de-Mesquita, H. B. ^{[23
,24
,25
]}

van Kranen, H. ^{[24
]}

Peeters, P. H. ^{[23
,26
]}

Weiderpass, E. ^{[27
,28
,29
,30
]}

Dorronsoro, M. ^{[31
]}

Jakszyn, P. ^{[32
]}

Sanchez, M. ^{[33
,34
,35
]}

Argueelles, M. ^{[36
]}

Huerta, J. M. ^{[34
,37
]}

Barricarte, A. ^{[38
,39
]}

Johansson, M. ^{[40
,41
]}

Ljuslinder, I. ^{[42
]}

Khaw, K. ^{[43
]}

Wareham, N. ^{[44
]}

Freisling, H. ^{[41
]}

Duarte-Salles, T. ^{[41
]}

Stepien, M. ^{[41
]}

Gunter, M. J. ^{[23
]}

Riboli, E. ^{[23
]}

机构：

[1] Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5018 Bergen, Norway

[2] Univ Bergen, Pharmacol Sect, N-5018 Bergen, Norway

[3] Maastricht Univ, CAPHRI, Sch Publ Hlth & Primary Care, Dept Epidemiol, Maastricht, Netherlands

[4] BEVITAl AS, Bergen, Norway

[5] Haukeland Hosp, Lab Clin Biochem, N-5021 Bergen, Norway

[6] Univ Bergen, Dept Clin Sci, Cardiol Sect, Bergen, Norway

[7] Haukeland Hosp, N-5021 Bergen, Norway

[8] Norwegian Inst Publ Hlth, Bergen, Norway

[9] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[10] Ctr Res Epidemiol & Populat Hlth CESP, INSERM, Villejuif, France

[11] Paris S Univ, Villejuif, France

[12] IGR, Villejuif, France

[13] INSERM, Res Ctr Lipids Nutr Canc, Dijon, France

[14] German Canc Res Ctr, Heidelberg, Germany

[15] Hellen Hlth Fdn, Athens, Greece

[16] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[17] Fdn IRCCS, Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[18] Canc Res & Prevent Inst ISPO, Mol & Nutrit Epidemiol Unit, Florence, Italy

[19] Univ Naples Federico II, Dipartimento Med Clin & Chirurgia, Naples, Italy

[20] Civile MP Arezzo Hosp, Canc Registry & Histopathol Unit, Ragusa, ASP, Italy

[21] Sch Publ Hlth, Turin, Italy

[22] HuGeF Fdn, Turin, Italy

[23] Imperial Coll London, Sch Publ Hlth, London, England

[24] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[25] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[26] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[27] UIT Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[28] Canc Registry Norway, Dept Res, Oslo, Norway

[29] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[30] Samfundet Folkhalsan, Dept Genet Epidemiol, Helsinki, Finland

[31] Publ Hlth Direct & Biodonostia Res Inst CIBERESP, Basque Reg Hlth Dept, San Sebastian, Spain

[32] Catalan Inst Oncol, Canc Epidemiol Res Program, Unit Nutr Environm & Canc, Barcelona, Spain

[33] Andalusian Sch Publ Hlth, Granada, Spain

[34] CIBERESP, Madrid, Spain

[35] Inst Invest Biosanitaria Granada Granada Ibs, Granada, Spain

[36] Publ Hlth Directorate, Oviedo, Spain

[37] Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[38] Publ Hlth Inst Navarra, Pamplona, Spain

[39] Consortium Biomed Res Epidemiol & Publ Hlth, Madrid, Spain

[40] Umea Univ, Dept Biobank Res, Umea, Sweden

[41] Int Agcy Res Canc IARC WHO, Lyon, France

[42] Umea Univ, Dept Radiat Sci, Umea, Sweden

[43] Univ Cambridge, Sch Clin Med, Cambridge, England

[44] Univ Cambridge, MRC Epidemiol Unit, Cambridge, England

来源：

ANNALS OF ONCOLOGY | 2014年 / 25卷 / 08期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

methionine; choline; betaine; dimethylglycine; colorectal cancer risk; population-based case-control study; B-VITAMIN; DIETARY CHOLINE; GENETIC-VARIANTS; FOLATE; REQUIREMENTS; EPIDEMIOLOGY; ESTROGEN; HEALTH;

D O I：

10.1093/annonc/mdu185

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Disturbances in one carbon metabolism may contribute to carcinogenesis by affecting methylation and synthesis of DNA. Choline and its oxidation product betaine are involved in this metabolism and can serve as alternative methyl group donors when folate status is low. Patients and methods: We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), to investigate plasma concentrations of the methyl donors methionine, choline, betaine (trimethylglycine), and dimethylglycine (DMG) in relation to colorectal cancer (CRC) risk. Our study included 1367 incident CRC cases (965 colon and 402 rectum) and 2323 controls matched by gender, age group, and study center. Multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for CRC risk were estimated by conditional logistic regression, comparing the fifth to the first quintile of plasma concentrations. Results: Overall, methionine (OR: 0.79, 95% CI: 0.63-0.99, P-trend = 0.05), choline (OR: 0.77, 95% CI: 0.60-0.99, P-trend = 0.07), and betaine (OR: 0.85, 95% CI: 0.66-1.09, P-trend = 0.06) concentrations were inversely associated with CRC risk of borderline significance. In participants with folate concentration below the median of 11.3 nmol/l, high betaine concentration was associated with reduced CRC risk (OR: 0.71, 95% CI: 0.50-1.00, P-trend = 0.02), which was not observed for those having a higher folate status. Among women, but not men, high choline concentration was associated with decreased CRC risk (OR: 0.62, 95% CI: 0.43-0.88, P-trend = 0.01). Plasma DMG was not associated with CRC risk. Conclusions: Individuals with high plasma concentrations of methionine, choline, and betaine may be at reduced risk of CRC.

引用

页码：1609 / 1615

页数：7

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