Oversecretion of Soluble CTLA-4 in Various Autoimmune Diseases Overlapping Celiac Disease

被引:5
作者
Pesce, Giampaola [1 ]
Auricchio, Renata [2 ]
Bagnasco, Marcello [1 ]
Saverino, Daniele [3 ]
机构
[1] Univ Genoa, Dept Internal Med, Autoimmun Unit, I-16132 Genoa, Italy
[2] Univ Naples Federico II, Dept Translat Med Sci, ELFID, Naples, Italy
[3] Univ Genoa, Dept Expt Med, Sect Human Anat, I-16132 Genoa, Italy
关键词
ASSOCIATION; MALIGNANCY; DIAGNOSIS; RISK; FORM;
D O I
10.1089/gtmb.2013.0350
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Aim: To evaluate the levels of soluble CTLA-4 (sCTLA-4) in sera of celiac disease (CD) patients with overlapping autoimmune diseases (OAD; diabetes mellitus, autoimmune thyroid diseases, inflammatory bowel diseases, and autoimmune polyendocrine syndromes). Methods: Sera from Italian patients with CD were obtained and enzyme-linked immunosorbent assay was used to measure sCTLA-4. Results: Consistently high serum sCTLA-4 levels were observed in CD (13.20 ng/mL, p<0.0001) and OAD (19.48 ng/mL, p<0.0001) compared to normal controls. A significant increase in the level of serum sCTLA-4 was observed in OAD (p=0.0273) compared to CD alone. At variance, no significant difference in the sCTLA-4 levels was observed when single OAD were compared. Conclusion: The present study shows for the first time a statistically significant increase of serum sCTLA-4 levels in CD patients with associated autoimmune disease (namely, CD and OAD) versus patients with CD alone. Previously, the potential genetic associations of several CTLA-4 polymorphisms to susceptibility to autoimmune diseases have been described, although the relationship between CTLA-4 polymorphisms and the ability to produce the soluble form is not fully clarified. CTLA-4 is a strong actor in the adaptive response: our data give supportive evidence of the common background of autoimmune diseases.
引用
收藏
页码:8 / 11
页数:4
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