Differential gene expression pattern of the response to neoadjuvant chemotherapy in locally advanced gastric cancer

被引：0
作者：
Feng, Daofu [1 ]
Shi, Wenzai [2 ]
Leong, Meiha [3 ]
Li, Tao [4 ]
He, Xianghui [1 ]
Zhang, Zhixiang [1 ]
机构：
[1] Tianjin Med Univ, Gen Hosp, Dept Gen Surg, 154 Anshan Rd, Tianjin 300052, Peoples R China
[2] Peking Univ, Int Hosp, Dept Hepatobiliary Surg, Beijing 102206, Peoples R China
[3] Kiang Wu Hosp, Dept Surg, Macau, Peoples R China
[4] Chinese Peoples Liberat Army Gen Hosp, Dept Gen Surg, Beijing 100028, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Gastric cancer; neoadjuvant chemotherapy; chemosensitivity; gene expression profiling; immune response; D2; GASTRECTOMY; ADJUVANT CHEMOTHERAPY; PHASE-II; S-1; OXALIPLATIN; PREDICTION; OUTCOMES; REPAIR; CISPLATIN; SURGERY;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
To improve the survival of gastric cancer, neoadjuvant chemotherapy followed by surgery has been a promising treatment protocol. However, non-responders have to suffer from adverse effects and miss the opportunity of other possible treatments. To elucidate the molecular basis of the response to neoadjuvant chemotherapy, the gene expression pattern was analyzed by a microarray-based method. Based on our previous retrospective study, we examined the gene expression of twelve patients who underwent S-1 plus oxaliplatin (SOX) neoadjuvant chemotherapy before curative surgery (R0) for stage III gastric cancer. Three tumor tissues without neoadjuvant chemotherapy were collected as the control group. These three groups were compared on functional and pathway enrichment analysis. The results were mainly shown that differentially expressed genes in responders and non-responders were highly enriched for genes involved in cytokine-cytokine receptor interaction and NK cell mediated cytotoxicity. Considering the drug sensitivity of oxaliplatin and S-1, microarray analysis significantly demonstrated 3 up-regulated genes and 1 down-regulated gene in DNA damage repair pathway which may play an important role in drug resistance (responders vs. non-responders). Thus, microarray analysis can efficiently evaluate the gene expression after neoadjuvant chemotherapy for gastric cancer, which may better understand tumor chemosensitivity.
引用
收藏
页码：21911 / 21921
页数：11
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