Modern imaging in Cushing's disease

被引:14
作者
Bashari, W. A. [1 ,2 ]
Gillett, D. [1 ,2 ,3 ]
MacFarlane, J. [1 ,2 ]
Powlson, A. S. [1 ,2 ]
Kolias, A. G. [4 ,5 ]
Mannion, R. [5 ]
Scoffings, D. J. [6 ]
Mendichovszky, I. A. [3 ,6 ]
Jones, J. [6 ]
Cheow, H. K. [3 ,6 ]
Koulouri, O. [1 ,2 ]
Gurnell, M. [1 ,2 ]
机构
[1] Univ Cambridge, Cambridge Endocrine Mol Imaging Grp, Metab Res Labs, Wellcome MRC Inst Metab Sci, Cambridge Biomed Campus, Cambridge CB2 0QQ, England
[2] Addenbrookes Hosp, Natl Inst Hlth Res, Cambridge Biomed Res Ctr, Cambridge Biomed Campus, Cambridge CB2 0QQ, England
[3] Addenbrookes Hosp, Dept Nucl Med, Cambridge Biomed Campus, Cambridge CB2 0QQ, England
[4] Univ Cambridge, Dept Neurosci, Cambridge Biomed Campus, Cambridge CB2 0QQ, England
[5] Addenbrookes Hosp, Dept Neurosurg, Cambridge Biomed Campus, Cambridge CB2 0QQ, England
[6] Addenbrookes Hosp, Dept Radiol, Cambridge Biomed Campus, Cambridge CB2 0QQ, England
基金
英国惠康基金;
关键词
Pituitary Cushing's; MRI; Molecular; functional imaging; PET; MICROADENOMAS;
D O I
10.1007/s11102-022-01236-w
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Management of Cushing's disease is informed by dedicated imaging of the sella and parasellar regions. Although magnetic resonance imaging (MRI) remains the investigation of choice, a significant proportion (30-50%) of corticotroph tumours are so small as to render MRI indeterminate or negative when using standard clinical sequences. In this context, alternative MR protocols [e.g. 3D gradient (recalled) echo, with acquisition of volumetric data] may allow detection of tumors that have not been previously visualized. The use of hybrid molecular imaging (e.g. C-11-methionine positron emission tomography coregistered with volumetric MRI) has also been proposed as an additional modality for localizing microadenomas.
引用
收藏
页码:709 / 712
页数:4
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