Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats

被引：86
作者：
Assis, L. [1 ]
Milares, L. P. [1 ]
Almeida, T. [1 ]
Tim, C. [2 ]
Magri, A. [1 ]
Fernandes, K. R. [1 ]
Medalha, C. [1 ]
Renno, A. C. Muniz [1 ]
机构：
[1] Univ Fed Sao Paulo, Dept Biosci, BR-11015020 Santos, SP, Brazil
[2] Univ Fed Sao Paulo, Dept Physiotherapy, Sao Carlos, SP, Brazil
来源：
OSTEOARTHRITIS AND CARTILAGE | 2016年 / 24卷 / 01期
基金：
巴西圣保罗研究基金会;
关键词：
Low-level laser therapy; Articular cartilage; Knee osteoarthritis; Rehabilitation; OXIDATIVE STRESS; EXPRESSION; PROTOCOL; PAIN; DEGRADATION; APOPTOSIS; CYTOKINES; WOMEN;
D O I：
10.1016/j.joca.2015.07.020
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Objective: The aim of this study was to evaluate the effects of an aerobic exercise training and low-level laser therapy (LLLT) (associated or not) on degenerative modifications and inflammatory mediators on the articular cartilage using an experimental model of knee OA. Material and methods: Fifty male Wistar rats were randomly divided into five groups: control group (CG); knee OA control group (OAC); OA plus exercise training group (OAT); OA plus LLLT group (OAL); OA plus exercise training associated with LLLT group (OATL). The exercise training (treadmill; 16 m/min; 50 min/day) and the laser irradiation (two points-medial and lateral side of the left joint; 24 sessions) started 4 weeks after the surgery, 3 days/week for 8 weeks. Results: The results showed that all treated groups showed (irradiated or not) a better pattern of tissue organization, with less fibrillation and irregularities along the articular surface and chondrocytes organization, a lower degenerative process measured by OARSI score and higher thickness values. Additionally, all treated group showed a reduced expression in IL-1 beta, caspase-3 and MMP-13 compared to OAC. Moreover, a lower caspase-3 expression was observed in OATL compared to OAL and OAT. Conclusion: These results suggest that exercise training and LLLT were effective in preventing cartilage degeneration and modulating inflammatory process induced by knee OA. (C) 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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收藏
页码：169 / 177
页数：9
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