A practical stereoselective synthesis of both enantiomers of threo- and erythro-β-hydroxy norvaline from (S)-serine derivatives

被引：18
|
作者：
Andrés, JM [1 ]
de Elena, N [1 ]
Pedrosa, R [1 ]
机构：
[1] Univ Valladolid, Fac Ciencias, Dept Quim Organ, E-47011 Valladolid, Spain
来源：
TETRAHEDRON | 2000年 / 56卷 / 11期
关键词：
diastereoselective synthesis; aminoalcohols; alkylzincs; aminoaldehydes;
D O I：
10.1016/S0040-4020(00)00038-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The four enantiopure diastereoisomers of beta-hydroxy norvaline have been prepared from L-serine in moderate chemical yield. The method is based on the diastereoselective addition of different organometallics to easily accessible serinal derivatives. (C) 2000 Elsevier Science Ltd. All rights reserved.
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收藏
页码：1523 / 1531
页数：9
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