New Strategies in Engineering T-cell Receptor Gene-Modified T cells to More Effectively Target Malignancies

被引：30

作者：

Schmitt, Thomas M. ^{[1
]}

Stromnes, Ingunn M. ^{[1
,2
]}

Chapuis, Aude G. ^{[1
]}

Greenberg, Philip D. ^{[1
,2
,3
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Program Immunol, Clin Res Div, Seattle, WA 98109 USA

[2] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

[3] Univ Washington, Sch Med, Dept Med, Div Med Oncol, Seattle, WA 98195 USA

来源：

CLINICAL CANCER RESEARCH | 2015年 / 21卷 / 23期

关键词：

DISSEMINATED MURINE LEUKEMIA; EXOME ANALYSIS REVEALS; METASTATIC MELANOMA; ADOPTIVE IMMUNOTHERAPY; TUMOR-ERADICATION; CANCER REGRESSION; TCR CHAINS; CD4(+); AFFINITY; THERAPY;

D O I：

10.1158/1078-0432.CCR-15-0860

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The immune system, T cells in particular, have the ability to target and destroy malignant cells. However, antitumor immune responses induced from the endogenous T-cell repertoire are often insufficient for the eradication of established tumors, as illustrated by the failure of cancer vaccination strategies or checkpoint blockade for most tumors. Genetic modification of T cells to express a defined T-cell receptor (TCR) can provide the means to rapidly generate large numbers of tumor-reactive T cells capable of targeting tumor cells in vivo. However, cell-intrinsic factors as well as immunosuppressive factors in the tumor microenvironment can limit the function of such gene-modified T cells. New strategies currently being developed are refining and enhancing this approach, resulting in cellular therapies that more effectively target tumors and that are less susceptible to tumor immune evasion. (C) 2015 AACR.

引用

页码：5191 / 5197

页数：7

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