Enhancing in vitro biocompatibility and corrosion protection of organic-inorganic hybrid sol-gel films with nanocrystalline hydroxyapatite

被引：34

作者：

El Hadad, A. A. ^{[1
,5
]}

Barranco, V. ^{[2
]}

Jimenez-Morales, A. ^{[3
]}

Peon, E. ^{[4
]}

Hickman, G. J. ^{[5
]}

Perry, C. C. ^{[5
]}

Galvan, J. C. ^{[1
]}

机构：

[1] Ctr Nacl Invest Met CSIC, Madrid, Spain

[2] Inst Ciencia Mat Madrid CSIC, Madrid, Spain

[3] Univ Carlos III Madrid, Dept Ciencia & Ingn Mat & Ingn Quim, Leganes, Spain

[4] Univ La Habana, Ctr Biomat, Havana, Cuba

[5] Nottingham Trent Univ, Sch Sci & Technol, Interdisciplinary Biomed Res Ctr, Nottingham NG11 8NS, England

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2014年 / 2卷 / 24期

关键词：

GAMMA-METHACRYLOXYPROPYLTRIMETHOXYSILANE; PROTEIN ADSORPTION; NANOCOMPOSITE MATERIALS; SILANE COATINGS; THIN-FILMS; SURFACE; CHEMISTRY; STEEL; ALUMINUM; ASSAY;

D O I：

10.1039/c4tb00173g

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Application of novel organic-inorganic hybrid sol-gel coatings containing dispersed hydroxyapatite (HAp) particles improves the biocompatibility, normal human osteoblast (NHOst) response in terms of osteoblast viability and adhesion of a Ti6Al4V alloy routinely used in medical implants. The incorporation of HAp particles additionally results in more effective barrier proprieties and improved corrosion protection of the Ti6Al4V alloy through higher degree of cross-linking in the organopolysiloxane matrix and enhanced film thickness.

引用

页码：3886 / 3896

页数：11

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