Cyclooxygenase-2 Expression in Pigs Infected Experimentally with Mycoplasma hyopneumoniae

被引：6
作者：
Andrada, M. [1 ]
Quesada-Canales, O. [1 ]
Suarez-Bonnet, A. [1 ]
Paz-Sanchez, Y. [1 ]
Espinosa de los Monteros, A. [1 ]
Rodriguez, F. [1 ]
机构：
[1] Univ Las Palmas Gran Canaria, Sch Vet, Inst Anim Hlth, Unit Vet Histol & Pathol, Arucas 35413, Gran Canaria, Spain
来源：
JOURNAL OF COMPARATIVE PATHOLOGY | 2014年 / 151卷 / 2-3期
关键词：
cyclooxygenase-2; Mycoplasma hyopneumoniae; pig; pneumonia; ENZOOTIC PNEUMONIA; NEUTROPHILS; LUNGS;
D O I：
10.1016/j.jcpa.2014.04.005
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Porcine enzootic pneumonia, primarily caused by Mycoplasma hyopneumoniae (Mh), is a contagious disease characterized by catarrhal bronchointerstitial pneumonia. Previous studies have evaluated immunohistochemically the distribution of Mb, different cellular populations and cytokines during Mb-induced pneumonia. Cyclooxygenase (COX)-2 is overexpressed during inflammatory responses by different cell types in the lung. The aim of this study was to elucidate the possible role of COX-2 in the pathogenesis of porcine enzootic pneumonia. COX-2 protein was detected by immunohistochemistry in formalin-fixed, paraffin wax-embedded lung tissues from 10 pigs infected experimentally with Mh. Ten pigs were inoculated intranasally with Mh and killed in pairs weekly from 1 to 5 weeks post inoculation. Three Mh-free pigs were taken as controls. Bronchial and bronchiolar epithelial cells, bronchial submucosal glands and a small number of macrophages in the bronchoalveolar exudate expressed COX-2. COX-2 protein was always associated with areas of pneumonia and expression was minimal in lungs from control pigs. These results suggest that COX-2 plays a role in the pathogenesis of Mh-infection. (C) 2014 Elsevier Ltd. All rights reserved.
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收藏
页码：271 / 276
页数：6
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