We report two cases of pazopanib (PAZ)-induced liver injury in patients with metastatic renal cell carcinoma. The first patient was a 70-year-old female who was diagnosed with right renal cell carcinoma and showed tumor embolism in the inferior vena cava. PAZ was started but discontinued after about one month due to a grade four liver injury. The second patient was a 60-year-old male who was diagnosed with left renal cell carcinoma and suspected multiple lung metastases. PAZ was started following a laparoscopic left radical nephrectomy but was stopped after about a month due to a grade three liver injury. We analyzed the plasma PAZ concentrations for treatment evaluation. High plasma PAZ concentrations were observed in both patients after PAZ treatment began. Severe liver injury after PAZ administration may be associated with high plasma PAZ concentrations; hence, we should reduce PAZ dosage early. We also recommend monitoring plasma PAZ concentrations, if possible, so that physicians can either reduce the dosage or discontinue treatment to avoid further liver damage.
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Queen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, EnglandQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Powles, Thomas
Bracarda, Sergio
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San Donato Hosp, Med Oncol Unit, I-52100 Arezzo, ItalyQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Bracarda, Sergio
Chen, Mei
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GlaxoSmithKline, Collegeville, PA 17426 USAQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Chen, Mei
Norry, Elliot
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GlaxoSmithKline, Collegeville, PA 17426 USAQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Norry, Elliot
Compton, Natalie
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GlaxoSmithKline, Uxbridge UB11 1BT, Middx, EnglandQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Compton, Natalie
Heise, Mark
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GlaxoSmithKline, Collegeville, PA 17426 USAQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Heise, Mark
Hutson, Thomas
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Texas Oncol & Baylor Sammons Canc Ctr, Dallas, TX 75246 USAQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Hutson, Thomas
Harter, Philipp
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Kliniken Essen Mitte, Dept Gynecol, D-45136 Essen, Germany
Kliniken Essen Mitte, Dept Gynecol Oncol, D-45136 Essen, GermanyQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Harter, Philipp
Carpenter, Christopher
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GlaxoSmithKline, Collegeville, PA 17426 USAQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Carpenter, Christopher
Pandite, Lini
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GlaxoSmithKline, Res Triangle Pk, NC 27709 USAQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Pandite, Lini
Kaplowitz, Neil
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Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USAQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
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Queen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, EnglandQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Powles, Thomas
Bracarda, Sergio
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h-index: 0
机构:
San Donato Hosp, Med Oncol Unit, I-52100 Arezzo, ItalyQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Bracarda, Sergio
Chen, Mei
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h-index: 0
机构:
GlaxoSmithKline, Collegeville, PA 17426 USAQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Chen, Mei
Norry, Elliot
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h-index: 0
机构:
GlaxoSmithKline, Collegeville, PA 17426 USAQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Norry, Elliot
Compton, Natalie
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h-index: 0
机构:
GlaxoSmithKline, Uxbridge UB11 1BT, Middx, EnglandQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Compton, Natalie
Heise, Mark
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h-index: 0
机构:
GlaxoSmithKline, Collegeville, PA 17426 USAQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Heise, Mark
Hutson, Thomas
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h-index: 0
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Texas Oncol & Baylor Sammons Canc Ctr, Dallas, TX 75246 USAQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Hutson, Thomas
Harter, Philipp
论文数: 0引用数: 0
h-index: 0
机构:
Kliniken Essen Mitte, Dept Gynecol, D-45136 Essen, Germany
Kliniken Essen Mitte, Dept Gynecol Oncol, D-45136 Essen, GermanyQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Harter, Philipp
Carpenter, Christopher
论文数: 0引用数: 0
h-index: 0
机构:
GlaxoSmithKline, Collegeville, PA 17426 USAQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Carpenter, Christopher
Pandite, Lini
论文数: 0引用数: 0
h-index: 0
机构:
GlaxoSmithKline, Res Triangle Pk, NC 27709 USAQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England
Pandite, Lini
Kaplowitz, Neil
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USAQueen Mary Univ London, Barts Canc Inst, Barts Expt Canc Med Ctr, London EC1A 7BE, England