Helicobacter pylori infection among offspring of patients with stomach cancer

被引:85
作者
Brenner, H
Bode, G
Boeing, H
机构
[1] Univ Ulm, Dept Epidemiol, D-89081 Ulm, Germany
[2] Univ Ulm, Dept Internal Med 1, D-7900 Ulm, Germany
[3] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany
关键词
D O I
10.1016/S0016-5085(00)70411-2
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background & Aims: A positive family history is associated with an increased risk of stomach cancer, We compared the prevalence of Helicobacter pylori infection, a known risk factor for stomach cancer, between subjects with and without parental history of stomach cancer to evaluate a potential role of H. pylori infection in familial aggregation of stomach cancer, Methods: A total of 1351 men and women aged 30-74 years who participated in the German Health and Nutrition Survey conducted in the western part of Germany in 1987-1988 were included in the study. Detailed information on sociodemographic factors, nutritional factors, and parental history of cancer was obtained by standardized interviews. Serum samples were analyzed for immunoglobulin G antibodies against H. pylori by enzyme-linked immunosorbent assay. Results: The prevalence of H, pylori infection was much higher (69%) among subjects with a parental history of stomach cancer than among other subjects (44%), This association persisted after control for potential confounders by multiple logistic regression (adjusted odds ratio, 2.7; 95% confidence interval, 1.3-5.9), and was particularly strong among subjects below age 55 (adjusted odds ratio, 5.1; 95% confidence interval, 1.6-16.1), Conclusions: These results suggest that familial aggregation of stomach cancer may be explained at least partly by familial clustering of H. pylori infection.
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页码:31 / 35
页数:5
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