Acute thrombocytopenia induced by trastuzumab due to complement reaction: A case report

被引：0

作者：

Chen, Guoping ^{[1
,2
]}

Ou, Jianghua ^{[1
]}

Liu, Jun ^{[3
]}

Liao, Haoran ^{[2
]}

Ding, Linwei ^{[2
]}

Fan, Pingming ^{[2
]}

Du, Guankui ^{[2
,3
,4
,5
,6
]}

机构：

[1] Xinjiang Med Univ, Dept Breast Surg, Affiliated Tumor Hosp, Urumqi, Peoples R China

[2] Hainan Med Univ, Dept Breast Surg, Affiliated Hosp 1, Haikou, Peoples R China

[3] Hainan Med Univ, Dept Immunol, Haikou, Peoples R China

[4] Hainan Med Univ, Key Lab Mol Biol, Haikou, Peoples R China

[5] Hainan Med Univ, Dept Biochem & Mol Biol, Haikou, Peoples R China

[6] Hainan Med Univ, Biotechnol & Biochem Lab, Haikou, Peoples R China

来源：

FRONTIERS IN MEDICINE | 2022年 / 9卷

关键词：

breast cancer; HER2; trastuzumab; dramatic thrombocytopenia; complement response; P-SELECTIN; EMTANSINE; SYSTEM;

D O I：

10.3389/fmed.2022.1037493

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundThe usual treatment option for HER2 breast cancer is targeted therapy with trastuzumab. The common adverse effects of trastuzumab treatment are thrombocytopenia, however, acute thrombocytopenia is rare and its mechanism is still largely unknown. Case presentationWe reported a patient who presented with acute thrombocytopenia on two consecutive occasions, and the predisposing factor was identified on the second occasion because of trastuzumab-only treatment. Routine blood results showed a dramatic increase in white blood cell count and neutrophil count after both trastuzumab treatments. Moreover, the complement reaction results suggested that the dramatic thrombocytopenia was probably due to platelet destruction after complement activation. ConclusionThis case suggests that it would be useful to perform a platelet complement reaction test before trastuzumab treatment in patients with HER2 breast cancer.

引用

页数：5

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