Microbiota: Overview and Implication in Immunotherapy-Based Cancer Treatments

被引：24

作者：

Brandi, Giovanni ^{[1
]}

Frega, Giorgio ^{[1
]}

机构：

[1] Univ Bologna, St Orsola Malpighi Hosp, Dept Expt Diagnost & Specialty Med, I-40138 Bologna, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 11期

关键词：

microbiota; microbiome; immunotherapy; adoptive cell transfer (ACT); CAR T-cell; TCR; TIL; checkpoint inhibitors; immuno-oncology; cancer; diet; HUMAN GUT MICROBIOTA; REGULATORY T-CELLS; IMMUNE HOMEOSTASIS; COMMENSAL BACTERIA; POTENTIAL ROLE; DIETARY FIBER; MUCUS BARRIER; INDUCTION; PROMOTES; HOST;

D O I：

10.3390/ijms20112699

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the last few years, the gut microbiota has gained increasing attention as a consequence of its emerging role as a modulator of the immune system. With the advent of the era of checkpoint inhibitors immunotherapy and adoptive cell transfer (ACT) in oncology, these findings became of primary relevance in light of experimental data that suggested the microbiota involvement as a plausible predictor of a good or poor response. These remarks justify the efforts to pinpoint the specific actions of the microbiota and to identify new strategies to favorably edit its composition.

引用

页数：16

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