Rapid Transition From Methadone to Buprenorphine Utilizing a Micro-dosing Protocol in the Outpatient Veteran Affairs Setting

被引：34

作者：

De Aquino, Joao P. ^{[1
,2
]}

Fairgrieve, Christopher ^{[3
]}

Klaire, Sukhpreet ^{[4
]}

Garcia-Vassallo, Gabriela ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

[2] VA Connecticut Healthcare Syst, US Dept Vet Affairs, West Haven, CT 06516 USA

[3] Univ Toronto, Ctr Addict & Mental Hlth, Dept Family & Community Med, Toronto, ON, Canada

[4] St Pauls Hosp, British Columbia Ctr Subst Use & Excellence HIV A, Vancouver, BC, Canada

来源：

JOURNAL OF ADDICTION MEDICINE | 2020年 / 14卷 / 05期

关键词：

buprenorphine induction; medication-assisted treatment; opioid addiction; rapid titration; DOSE METHADONE; WITHDRAWAL; OVERDOSE; DRUG;

D O I：

10.1097/ADM.0000000000000618

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Objectives: Alternative transition protocols from methadone to buprenorphine in the treatment of opioid use disorder (OUD) are needed to reduce the risk of precipitated withdrawal and opioid use during induction. Methods: Case report (n = 1). Results: One patient with OUD underwent a rapid microinduction outpatient protocol that did not cause precipitated withdrawal or require preceding taper before cessation of methadone. The induction was carried out safely in the outpatient setting. Conclusions: This report provides a patient-centered approach demonstrating feasibility and cost-effectiveness of rapid transition to buprenorphine in the US outpatient psychiatry setting. Barriers to adherence to opioid agonist therapy may be reduced using this protocol.

引用

页码：E271 / E273

页数：3

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