Survival After Cancer in Italian Persons With AIDS, 1986-2005: A Population-Based Estimation

被引：19

作者：

Dal Maso, Luigino ^{[1
]}

Suligoi, Barbara ^{[2
]}

Franceschi, Silvia ^{[3
]}

Braga, Claudia ^{[1
]}

Buzzoni, Carlotta ^{[4
,5
]}

Polesel, Jerry ^{[1
]}

Zucchetto, Antonella ^{[1
,6
]}

Piselli, Pierluca ^{[7
]}

Falcini, Fabio ^{[8
]}

Caldarella, Adele

Zanetti, Roberto ^{[9
]}

Vercelli, Marina ^{[10
,11
]}

Guzzinati, Stefano ^{[12
]}

Russo, Antonio ^{[13
]}

Tagliabue, Giovanna ^{[14
]}

Iachetta, Francesco ^{[15
]}

Ferretti, Stefano ^{[16
]}

Limina, Rosa M. ^{[17
]}

Mangone, Lucia ^{[18
]}

Michiara, Maria ^{[19
]}

Stracci, Fabrizio ^{[20
,21
]}

Pirino, Daniela R. ^{[22
]}

Piffer, Silvano ^{[23
]}

Giacomin, Adriano ^{[24
]}

Vitarelli, Susanna ^{[25
]}

Mazzoleni, Guido ^{[26
]}

Iannelli, Arturo ^{[27
]}

Contrino, Maria L. ^{[28
]}

Fusco, Mario ^{[29
]}

Tumino, Rosario ^{[30
]}

Fanetti, Anna C. ^{[31
]}

De Paoli, Paolo ^{[32
]}

Decarli, Adriano ^{[6
]}

Serraino, Diego ^{[1
,33
]}

机构：

[1] CRO Aviano Natl Canc Inst, Epidemiol & Biostat Unit, I-33081 Aviano, Pordenone, Italy

[2] Ist Super Sanita, I-00161 Rome, Italy

[3] Int Agcy Res Canc, F-69372 Lyon, France

[4] AIRTUM Database, Florence, Italy

[5] Ist Studio & Prevenz Oncol, UO Epidemiol Clin & Descritt, Tuscany Canc Registry, Florence, Italy

[6] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy

[7] INMI L Spallanzani IRCCS, Dept Epidemiol, Rome, Italy

[8] Canc Inst Romagna IRCCS, Romagna Canc Registry, Meldola, Italy

[9] Oncol Prevent Ctr CPO, Piedmont Canc Registry, Turin, Italy

[10] Univ Genoa, Ist Nazl Ric Canc, IRCSS Azienda Univ Osped San Martino IST, Registro Tumori Reg Liguria, Genoa, Italy

[11] Univ Genoa, Dipartimento Sci Salute, Genoa, Italy

[12] Ist Oncol Veneto IRCCS, Registro Tumori Veneto, Padua, Italy

[13] Milan Hlth Author, Milan Canc Registry, Epidemiol Unit, Milan, Italy

[14] Natl Canc Inst, Lombardia Canc Registry, I-20133 Milan, Varese Province, Italy

[15] Univ Modena & Reggio Emilia, Dept Oncol Hematol & Resp Dis, Modena Canc Registry, Modena, Italy

[16] Univ Ferrara, Ferrara Canc Registry, I-44100 Ferrara, Italy

[17] Canc Registry, Brescia Hlth Unit, Brescia, Italy

[18] Arcispedale S Maria Nuova, SC Stat Qualita & Studi Clin IRCCS, Reggio Emilia, Italy

[19] Univ Hosp Parma, Parma Prov Canc Registry, Parma, Italy

[20] Univ Perugia, Dept Med & Surg Specialties, Umbria Canc Registry, I-06100 Perugia, Italy

[21] Univ Perugia, Sect Publ Hlth, I-06100 Perugia, Italy

[22] Canc Registry Sassari, Sassari, Italy

[23] Registro Tumori Prov Trento, Serv Epidemiol Clin & Valutat, Trento, Italy

[24] Prov Biella CPO, Registro Tumori Piemonte, Biella, Italy

[25] Univ Camerino, Dipartimento Med Sperimentale & Sanita Pubbl, Macerata Prov Canc & Mortal Registry, I-62032 Camerino, Italy

[26] Alto Adige Sudtirol Canc Registry, Bolzano, Italy

[27] Salerno Canc Registry, Salerno, Italy

[28] ASP Siracusa, Siracusa Canc Registry, Siracusa, Italy

[29] ASL Napoli 3 Sud, Campania Reg Canc Registry, Naples, Italy

[30] ASP Ragusa, Civ MP Arezzo Hosp, Canc Registry & Histopathol Unit, Ragusa, Italy

[31] Local Hlth Agcy, Sondrio Canc Registry, Sondrio, Italy

[32] CRO Aviano Natl Canc Inst, Sci Directorate, Aviano, Italy

[33] Cent Hlth Direct, Friuli Venezia Giulia Canc Registry, Udine, Italy

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2014年 / 66卷 / 04期

关键词：

survival; AIDS patients; cancer; hazard ratio; ACTIVE ANTIRETROVIRAL THERAPY; HIV-INFECTED PATIENTS; NON-HODGKIN-LYMPHOMA; HEPATOCELLULAR-CARCINOMA; EXCESS MORTALITY; KAPOSIS-SARCOMA; LUNG-CANCER; IMMUNODEFICIENCY; DEATH; RISK;

D O I：

10.1097/QAI.0000000000000184

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Cancer survival in persons with AIDS (PWA) after introduction of antiretroviral therapies remains poorly characterized. The aim is to provide population-based estimates of cancer survival, overall and for the most important cancer types in PWA, and a comparison with persons without AIDS (non-PWA) affected by the same cancer. Methods: PWA with cancer at AIDS diagnosis or thereafter were individually matched with non-PWA by type of cancer, sex, age, year of diagnosis, area of living, and, for lymphomas, histological subtype. Five-year observed survival and hazard ratios (HRs) of death in PWA versus non-PWA with 95% confidence intervals (CIs) were estimated. Results: We included 2262 Italian PWA and 4602 non-PWA with cancer diagnosed during 1986-2005. Between 1986 and 1995, and 1996 and 2005, 5-year survival for all cancers in PWA improved from 12% to 41% and the corresponding HR versus non-PWA decreased from 5.1 (95% CI: 4.3 to 6.1) to 2.9 (95% CI: 2.6 to 3.3). During 1996-2005, HRs were 2.0 (95% CI: 1.4 to 2.9) for Kaposi sarcoma, 3.4 (95% CI: 2.9 to 4.1) for non-Hodgkin lymphoma, and 2.4 (95% CI: 1.4 to 4.0) for cervical cancer. HRs were 2.5 (95% CI: 2.1 to 3.1) for all non-AIDS-defining cancers, 5.9 (95% CI: 3.1 to 11.2) for Hodgkin lymphoma, and 7.3 (95% CI: 2.8 to 19.2) for nonmelanoma skin cancer. A <= 3-fold survival difference was found for cancers of the stomach, liver, anus, lung, brain, and the most aggressive lymphoma subtypes. Conclusions: The persisting, although narrowing, gap in cancer survival between PWA and non-PWA indicates the necessity of enhancing therapeutic approaches, so that PWA can be provided the same chances of survival observed in the general population, and improving cancer prevention and screening.

引用

页码：428 / 435

页数：8

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