Ligand identification for G-protein-coupled receptors: a lead generation perspective

被引：36

作者：

Bleicher, KH ^{[1
]}

Green, LG ^{[1
]}

Martin, RE ^{[1
]}

Rogers-Evans, M ^{[1
]}

机构：

[1] F Hoffmann La Roche & Co Ltd, Div Pharmaceut, Lead Generat, PRBDCI, CH-4070 Basel, Switzerland

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2004年 / 8卷 / 03期

关键词：

D O I：

10.1016/j.cbpa.2004.04.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review addresses strategies for the generation of ligands for G-protein-coupled receptors outside classical high-throughput screening and literature based approaches. These range from the chemical intuition-based strategies of endogenous ligand elaboration and privileged structure decoration to the in silico approaches of virtual screening and de novo design. Examples are cited where supporting pharmacological data has been presented.

引用

页码：287 / 296

页数：10

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