Characterization of omega-3 tablets

被引：7
|
作者：
Vestland, Tina Lien [1 ,2 ]
Jacobsen, Oyvind [3 ]
Sande, Sverre Arne [2 ]
Myrset, Astrid Hilde
Klaveness, Jo [1 ,2 ]
机构：
[1] Omegatri AS, N-0422 Oslo, Norway
[2] Univ Oslo, Sch Pharm, N-0316 Oslo, Norway
[3] Univ Oslo, Dept Chem, N-0315 Oslo, Norway
来源：
FOOD CHEMISTRY | 2016年 / 197卷
关键词：
Omega-3; EPA; DHA; Fish oil; Powder; Cyclodextrin; Tablets; POLYUNSATURATED FATTY-ACIDS; LINOLEIC-ACID; CYCLODEXTRIN COMPLEXES; MICROENCAPSULATION; ASSOCIATION;
D O I：
10.1016/j.foodchem.2015.10.142
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Omega-3 nutraceuticals are extensively used as health supplements worldwide. Various administration forms for delivery of omega-3 are available. However, the niche omega-3 tablets have so far remained unexplored. In this work tablets containing 25-40% (w/w) omega-3 oil as triglycerides or ethyl esters were prepared utilizing a direct compaction grade powder with beta-cyclodextrin as encapsulating agent. It was found that powders with up to 35% (w/w) triglyceride oil and 30% (w/w) ethyl ester oil, respectively, can be directly compressed into tablets of excellent quality. Physical properties of omega-3 containing powders and tablets are described. The powder X-ray diffractograms of the powders and crushed tablets show evidence of the formation of new crystalline phases not present in beta-cyclodextrin. In addition, H-1 NMR data suggest that the ethyl esters form inclusion complexes with beta-cyclodextrin. Compaction of other, commercially available, omega-3 powders was performed as a comparison and deemed unsuccessful. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：496 / 502
页数：7
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