Alcohol consumption is associated with an increased risk of distal colon and rectal cancer in Japanese men: The Miyagi Cohort Study

被引:38
作者
Akhter, Munira
Kuriyama, Shinichi
Nakaya, Naoki
Shimazu, Taichi
Ohmori, Kaori
Nishino, Yoshikazu
Tsubono, Yoshitaka
Fukao, Akira
Tsuji, Ichiro
机构
[1] Tohoku Univ, Grad Sch Med, Dept Publ Hlth & Forens Med, Div Epidemiol,Aoba Ku, Sendai, Miyagi 9808575, Japan
[2] Miyagi Canc Ctr, Res Inst, Div Epidemiol, Natori, Miyagi, Japan
[3] Tohoku Univ, Sch Publ Policy, Div Hlth Policy, Sendai, Miyagi, Japan
[4] Yamagata Univ, Sch Med, Dept Publ Hlth, Yamagata 99023, Japan
关键词
alcohol; colorectal cancer; prospective study; anatomical subsites; men; Japan;
D O I
10.1016/j.ejca.2006.09.020
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The association between alcohol consumption and the risk of cancer of the proximal or-distal colon or rectum remains controversial. We examined this association in a large population-based cohort of Japanese men. In 1990, a self-administered questionnaire on alcohol drinking and other health habits was delivered to 25,279 Japanese men aged 40 to 64 years of age. After exclusion of subjects who gave incomplete responses on alcohol drinking or prevalent cancer cases at the baseline, a total of 21,199 men remained. Of these, 307 men were diagnosed as having colorectal cancer after 11 years of follow-up. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), with adjustments made for potential confounders. Compared with never drinkers, past and current drinkers had multivariate HRs of 1.1 (95% CI, 0.6-1.9) and 1.6 (95% CI, 1.1-2.2) for colorectal cancer, respectively A dose-response relationship with current volume of alcohol drinkers was observed for cancer of the distal colon and rectum, but not for proximal colon. The multivariate HRs for distal colon and rectal cancer among current heavy drinkers (45.6 g or more ethanol per day) as compared with never drinkers were 4.2 (1.6-10.7; p for trend = 0.0002) and 1.8 (1.1-3.2; p for trend = 0.04), respectively. In contrast, no significant linear association was found for proximal colon cancer (p for trend = 0.2). These data indicate that alcohol consumption in Japanese men is associated with a statistically significant increased risk of cancer of the distal colon and rectum, but not cancer of the proximal colon. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:383 / 390
页数:8
相关论文
共 40 条
[31]   Nutrition, lifestyle and colorectal cancer incidence: a prospective investigation of 10 998 vegetarians and non-vegetarians in the United Kingdom [J].
Sanjoaquin, MA ;
Appleby, PN ;
Thorogood, M ;
Mann, JI ;
Key, TJ .
BRITISH JOURNAL OF CANCER, 2004, 90 (01) :118-121
[32]   Height, weight, and alcohol consumption in relation to the risk of colorectal cancer in Japan: a prospective study [J].
Shimizu, N ;
Nagata, C ;
Shimizu, H ;
Kametani, M ;
Takeyama, N ;
Ohnuma, T ;
Matsushita, S .
BRITISH JOURNAL OF CANCER, 2003, 88 (07) :1038-1043
[33]   The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action [J].
Smith, ML ;
Hawcroft, G ;
Hull, MA .
EUROPEAN JOURNAL OF CANCER, 2000, 36 (05) :664-674
[34]  
*STAT INF DEP MIN, 2004, VIT STAT JAP 2003
[35]   PROSPECTIVE-STUDY OF ALCOHOL INTAKE AND LARGE-BOWEL CANCER [J].
STEMMERMANN, GN ;
NOMURA, AMY ;
CHYOU, PH ;
YOSHIZAWA, C .
DIGESTIVE DISEASES AND SCIENCES, 1990, 35 (11) :1414-1420
[36]   Alcohol consumption and risk of colon cancer: Evidence from the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study [J].
Su, LYJ ;
Arab, L .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2004, 50 (02) :111-119
[37]   Colorectal cancer in Denmark 1943-1997 [J].
Thygesen, LC ;
Gronbæk, M ;
Johansen, C .
DISEASES OF THE COLON & RECTUM, 2004, 47 (07) :1232-1241
[38]   Alcohol consumption and colorectal cancer risk: Findings from the JACC study [J].
Wakai, K ;
Kojima, M ;
Tamakoshi, K ;
Watanabe, Y ;
Hayakawa, N ;
Suzuki, K ;
Hashimoto, S ;
Kawado, M ;
Tokudome, S ;
Suzuki, S ;
Ozasa, K ;
Toyoshima, H ;
Ito, Y ;
Tamakoshi, A .
JOURNAL OF EPIDEMIOLOGY, 2005, 15 :S173-S179
[39]   Constipation, laxative use and risk of colorectal cancer: The Miyagi Cohort Study [J].
Watanabe, T ;
Nakaya, N ;
Kurashima, K ;
Kuriyama, S ;
Tsubono, Y ;
Tsuji, I .
EUROPEAN JOURNAL OF CANCER, 2004, 40 (14) :2109-2115
[40]   ALCOHOL, PHYSICAL-ACTIVITY AND OTHER RISK-FACTORS FOR COLORECTAL-CANCER - A PROSPECTIVE-STUDY [J].
WU, AH ;
PAGANINIHILL, A ;
ROSS, RK ;
HENDERSON, BE .
BRITISH JOURNAL OF CANCER, 1987, 55 (06) :687-694