Lipopolysaccharide-binding protein is associated with arterial stiffness in patients with type 2 diabetes: a cross-sectional study

被引：41

作者：

Sakura, Takeshi ^{[1
]}

Morioka, Tomoaki ^{[1
]}

Shioi, Atsushi ^{[2
,3
]}

Kakutani, Yoshinori ^{[1
]}

Miki, Yuya ^{[1
]}

Yamazaki, Yuko ^{[1
]}

Motoyama, Koka ^{[1
]}

Mori, Katsuhito ^{[4
]}

Fukumoto, Shinya ^{[5
]}

Shoji, Tetsuo ^{[2
,3
]}

Emoto, Masanori ^{[1
]}

Inaba, Masaaki ^{[1
,3
]}

机构：

[1] Osaka City Univ, Dept Metab Endocrinol & Mol Med, Grad Sch Med, Abeno Ku, 1-4-3 Asahi Machi, Osaka 5458585, Japan

[2] Osaka City Univ, Grad Sch Med, Dept Vasc Med, Abeno Ku, 1-4-3 Asahi Machi, Osaka 5458585, Japan

[3] Osaka City Univ, Grad Sch Med, Vasc Sci Ctr Translat Res, Abeno Ku, 1-4-3 Asahi Machi, Osaka 5458585, Japan

[4] Osaka City Univ, Grad Sch Med, Dept Nephrol, Abeno Ku, 1-4-3 Asahi Machi, Osaka 5458585, Japan

[5] Osaka City Univ, Grad Sch Med, Dept Premier Prevent Med, Abeno Ku, 1-4-3 Asahi Machi, Osaka 5458585, Japan

来源：

CARDIOVASCULAR DIABETOLOGY | 2017年 / 16卷

基金：

日本学术振兴会;

关键词：

Lipopolysaccharide-binding protein; Arterial stiffness; Pulse wave velocity; Type; 2; diabetes; INTIMA-MEDIA THICKNESS; ALL-CAUSE MORTALITY; METABOLIC SYNDROME; CARDIOVASCULAR MORTALITY; AORTIC STIFFNESS; CAROTID ATHEROSCLEROSIS; OVERWEIGHT PATIENTS; VISCERAL ADIPOSITY; MMP-9; EXPRESSION; SEX-DIFFERENCES;

D O I：

10.1186/s12933-017-0545-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Lipopolysaccharide (LPS)-binding protein (LBP) is an acute-phase reactant that mediates immune responses triggered by LPS. Recent evidence indicates the association of circulating LBP levels with obesity, diabetes, and cardiovascular diseases. In this study, we aimed to investigate the relationship between serum LBP levels and arterial stiffness in patients with type 2 diabetes. Methods: A total of 196 patients with type 2 diabetes, including 101 men and 95 women, were enrolled in this cross-sectional study. Fasting serum LBP levels were determined by enzyme-linked immunosorbent assay. Arterial stiffness was assessed by measuring the aortic pulse wave velocity (PWV). Results: The mean values of serum LBP and aortic PWV were 18.2 mu g/mL and 1194 cm/s, respectively. Serum LBP levels were positively correlated with body mass index, triglycerides, high-sensitivity C-reactive protein, and insulin resistance index and were negatively correlated with high-density lipoprotein cholesterol. They were, however, not significantly correlated with aortic PWV in univariate analyses. Multivariate analysis revealed that serum LBP levels were independently and positively associated with aortic PWV (beta = 0.135, p = 0.026) after adjusting for age, sex, body mass index, albumin, high-sensitivity C-reactive protein, and other cardiovascular risk factors. Further analyses revealed that the impact of serum LBP levels on aortic PWV was modified by sex, and the association between serum LBP levels and aortic PWV was found to be significant only in men. Conclusions: Serum LBP levels are associated with arterial stiffness, independent of obesity and traditional cardiovascular risk factors, especially in men with type 2 diabetes. This study indicates a potential role of the LPS/LBP-induced innate immunity in the development and progression of arterial stiffness in type 2 diabetes.

引用

页数：8

共 53 条

[1] Soluble CD14 and aortic stiffness in a population-based study [J].

Amar, J ;

Ruidavets, JB ;

Sollier, CBD ;

Bongard, V ;

Boccalon, H ;

Chamontin, B ;

Drouet, L ;

Ferrières, J .

JOURNAL OF HYPERTENSION, 2003, 21 (10) :1869-1877

[2] Standards of Medical Care in Diabetes-2014 [J].

不详 .

DIABETES CARE, 2014, 37 :S14-S80

[3] Gender difference in tumor necrosis factor-α production in human neutrophils stimulated by lipopolysaccharide and interferon-γ [J].

Aomatsu, Megumi ;

Kato, Takayuki ;

Kasahara, Emiko ;

Kitagawa, Seiichi .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 441 (01) :220-225

[4] Individual diet has sex-dependent effects on vertebrate gut microbiota [J].

Bolnick, Daniel I. ;

Snowberg, Lisa K. ;

Hirsch, Philipp E. ;

Lauber, Christian L. ;

Org, Elin ;

Parks, Brian ;

Lusis, Aldons J. ;

Knight, Rob ;

Caporaso, J. Gregory ;

Svanback, Richard .

NATURE COMMUNICATIONS, 2014, 5

[5] Is visceral adiposity a modifier for the impact of blood pressure on arterial stiffness and albuminuria in patients with type 2 diabetes? [J].

Bouchi, Ryotaro ;

Ohara, Norihiko ;

Asakawa, Masahiro ;

Nakano, Yujiro ;

Takeuchi, Takato ;

Murakami, Masanori ;

Sasahara, Yuriko ;

Numasawa, Mitsuyuki ;

Minami, Isao ;

Izumiyama, Hajime ;

Hashimoto, Koshi ;

Yoshimoto, Takanobu ;

Ogawa, Yoshihiro .

CARDIOVASCULAR DIABETOLOGY, 2016, 15

[6] Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice [J].

Cani, Patrice D. ;

Bibiloni, Rodrigo ;

Knauf, Claude ;

Neyrinck, Audrey M. ;

Delzenne, Nathalle M. ;

Burcelin, Remy .

DIABETES, 2008, 57 (06) :1470-1481

[7] Metabolic endotoxemia initiates obesity and insulin resistance [J].

Cani, Patrice D. ;

Amar, Jacques ;

Iglesias, Miguel Angel ;

Poggi, Marjorie ;

Knauf, Claude ;

Bastelica, Delphine ;

Neyrinck, Audrey M. ;

Fava, Francesca ;

Tuohy, Kieran M. ;

Chabo, Chantal ;

Waget, Aurelie ;

Delmee, Evelyne ;

Cousin, Beatrice ;

Sulpice, Thierry ;

Chamontin, Bernard ;

Ferrieres, Jean ;

Tanti, Jean-Francois ;

Gibson, Glenn R. ;

Casteilla, Louis ;

Delzenne, Nathalie M. ;

Alessi, Marie Christine ;

Burcelin, Remy .

DIABETES, 2007, 56 (07) :1761-1772

[8] Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality - The cardiovascular health study [J].

Cao, Jie J. ;

Arnold, Alice M. ;

Manolio, Teri A. ;

Polak, Joseph F. ;

Psaty, Bruce M. ;

Hirsch, Calvin H. ;

Kuller, Lewis H. ;

Cushman, Mary .

CIRCULATION, 2007, 116 (01) :32-38

[9] Arterial Stiffness Is Positively Associated With 18F-fluorodeoxyglucose Positron Emission Tomography-Assessed Subclinical Vascular Inflammation in People With Early Type 2 Diabetes [J].

de Boer, Stefanie A. ;

Hovinga-de Boer, Marieke C. ;

Heerspink, Hiddo J. L. ;

Lefrandt, Joop D. ;

van Roon, Arie M. ;

Lutgers, Helen L. ;

Glaudemans, Andor W. J. M. ;

Kamphuisen, Pieter W. ;

Slart, Riemer H. J. A. ;

Mulder, Douwe J. .

DIABETES CARE, 2016, 39 (08) :1440-1447

[10] Etiology of End-Stage Renal Disease and Arterial Stiffness among Hemodialysis Patients [J].

El Ghoul, Balsam ;

Daaboul, Yazan ;

Korjian, Serge ;

El Alam, Andrew ;

Mansour, Anthony ;

Hariri, Essa ;

Samad, Salam ;

Salameh, Pascale ;

Dahdah, Georges ;

Blacher, Jacques ;

Safar, Michel E. ;

Bahous, Sola Aoun .

BIOMED RESEARCH INTERNATIONAL, 2017, 2017

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