Abnormal composition of gut microbiota is associated with resilience versus susceptibility to inescapable electric stress

被引：75

作者：

Zhang, Kai ^{[1
,2
]}

Fujita, Yuko ^{[1
]}

Chang, Lijia ^{[1
]}

Qui, Youge ^{[1
]}

Pu, Yaoyu ^{[1
]}

Wang, Siming ^{[1
]}

Shirayama, Yukihiko ^{[1
,3
]}

Hashimoto, Kenji ^{[1
]}

机构：

[1] Chiba Univ, Ctr Forens Mental Hlth, Div Clin Neurosci, Chiba 2608670, Japan

[2] Anhui Med Univ, Chaohu Hosp, Dept Psychiat, Hefei 238000, Anhui, Peoples R China

[3] Teikyo Univ, Chiba Med Ctr, Dept Psychiat, Ichihara, Chiba 2990111, Japan

来源：

TRANSLATIONAL PSYCHIATRY | 2019年 / 9卷 / 1期

关键词：

CHRONIC SOCIAL DEFEAT; CHAIN FATTY-ACIDS; LEARNED HELPLESSNESS; REGIONAL DIFFERENCES; BRAIN; DEPRESSION; BEHAVIOR; PSYCHOBIOLOGY; MECHANISMS; EXPRESSION;

D O I：

10.1038/s41398-019-0571-x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Increasing evidence indicates that abnormalities in the composition of gut microbiota might play a role in stress-related disorders. In the learned helplessness (LH) paradigm, similar to 60-70% rats are susceptible to LH in the face of inescapable electric stress. The role of gut microbiota in susceptibility in the LH paradigm is unknown. In this study, male rats were exposed to inescapable electric stress under the LH paradigm. The compositions of gut microbiota and short-chain fatty acids were assessed in fecal samples from control rats, non-LH (resilient) rats, and LH (susceptible) rats. Members of the order Lactobacillales were present at significantly higher levels in the susceptible rats than in control and resilient rats. At the family level, the number of Lactobacillaceae in the susceptible rats was significantly higher than in control and resilient rats. At the genus level, the numbers of Lactobacillus, Clostridium cluster III, and Anaerofustis in susceptible rats were significantly higher than in control and resilient rats. Levels of acetic acid and propionic acid in the feces of susceptible rats were lower than in those of control and resilient rats; however, the levels of lactic acid in the susceptible rats were higher than those of control and resilient rats. There was a positive correlation between lactic acid and Lactobacillus levels among these three groups. These findings suggest that abnormal composition of the gut microbiota, including organisms such as Lactobacillus, contributes to susceptibility versus resilience to LH in rats subjected to inescapable electric foot shock Therefore, it appears likely that brain-gut axis plays a role in stress susceptibility in the LH paradigm.

引用

页数：9

共 64 条

[1] Glyphosate based-herbicide exposure affects gut microbiota, anxiety and depression-like behaviors in mice [J].

Aitbali, Yassine ;

Ba-M'hamed, Saadia ;

Elhidar, Najoua ;

Nafis, Ahmed ;

Soraa, Nabila ;

Bennis, Mohamed .

NEUROTOXICOLOGY AND TERATOLOGY, 2018, 67 :44-49

[2] Effect of Wheat Bran on Fecal Butyrate-Producing Bacteria and Wheat Bran Combined with Barley on Bacteroides Abundance in Japanese Healthy Adults [J].

Aoe, Seiichiro ;

Nakamura, Fumiko ;

Fujiwara, Suguru .

NUTRIENTS, 2018, 10 (12)

[3] The Impact of Microbiota on Brain and Behavior: Mechanisms & Therapeutic Potential [J].

Borre, Yuliya E. ;

Moloney, Rachel D. ;

Clarke, Gerard ;

Dinan, Timothy G. ;

Cryan, John F. .

MICROBIAL ENDOCRINOLOGY: THE MICROBIOTA-GUT-BRAIN AXIS IN HEALTH AND DISEASE, 2014, 817 :373-403

[4] Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve [J].

Bravo, Javier A. ;

Forsythe, Paul ;

Chew, Marianne V. ;

Escaravage, Emily ;

Savignac, Helene M. ;

Dinan, Timothy G. ;

Bienenstock, John ;

Cryan, John F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (38) :16050-16055

[5] Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice [J].

Burokas, Aurelijus ;

Arboleya, Silvia ;

Moloney, Rachel D. ;

Peterson, Veronica L. ;

Murphy, Kiera ;

Clarke, Gerard ;

Stanton, Catherine ;

Dinan, Timothy G. ;

Cryan, John F. .

BIOLOGICAL PSYCHIATRY, 2017, 82 (07) :472-487

[6] Peripheral administration of lactate produces antidepressant-like effects [J].

Carrard, A. ;

Elsayed, M. ;

Margineanu, M. ;

Boury-Jamot, B. ;

Fragniere, L. ;

Meylan, E. M. ;

Petit, J-M ;

Fiumelli, H. ;

Magistretti, P. J. ;

Martin, J-L .

MOLECULAR PSYCHIATRY, 2018, 23 (02) :392-399

[7] Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function [J].

Cussotto, Sofia ;

Strain, Conall R. ;

Fouhy, Fiona ;

Strain, Ronan G. ;

Peterson, Veronica L. ;

Clarke, Gerard ;

Stanton, Catherine ;

Dinan, Timothy G. ;

Cryan, John F. .

PSYCHOPHARMACOLOGY, 2019, 236 (05) :1671-1685

[8] The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective [J].

Cussotto, Sofia ;

Sandhu, Kiran V. ;

Dinan, Timothy G. ;

Cryan, John F. .

FRONTIERS IN NEUROENDOCRINOLOGY, 2018, 51 :80-101

[9] Resilience and immunity [J].

Dantzer, Robert ;

Cohen, Sheldon ;

Russo, Scott J. ;

Dinan, Timothy G. .

BRAIN BEHAVIOR AND IMMUNITY, 2018, 74 :28-42

[10] The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism [J].

den Besten, Gijs ;

van Eunen, Karen ;

Groen, Albert K. ;

Venema, Koen ;

Reijngoud, Dirk-Jan ;

Bakker, Barbara M. .

JOURNAL OF LIPID RESEARCH, 2013, 54 (09) :2325-2340

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