Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection

被引：58

作者：

Crellen, Thomas ^{[1
,2
,4
]}

Allan, Fiona ^{[3
]}

David, Sophia ^{[2
]}

Durrant, Caroline ^{[2
]}

Huckvale, Thomas ^{[2
]}

Holroyd, Nancy ^{[2
]}

Emery, Aidan M. ^{[3
]}

Rollinson, David ^{[3
]}

Aanensen, David M. ^{[1
,2
]}

Berriman, Matthew ^{[2
]}

Webster, Joanne P. ^{[1
,4
]}

Cotton, James A. ^{[2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, St Marys Campus,Norfolk Pl, London W2 1PG, England

[2] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England

[3] Nat Hist Museum, Dept Life Sci, Cromwell Rd, London SW7 5BD, England

[4] Univ London, Royal Vet Coll, Dept Pathol & Pathogen Biol, London AL9 7TA, Herts, England

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

英国惠康基金;

关键词：

MIDDLE STONE-AGE; UPPER SEMLIKI VALLEY; PHYLOGENETIC ANALYSIS; POSITIVE SELECTION; AFRICA; EPIDEMIOLOGY; EVOLUTION; ORIGIN; TRANSCRIPTOME; SEPARATION;

D O I：

10.1038/srep20954

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Schistosoma mansoni is a parasitic fluke that infects millions of people in the developing world. This study presents the first application of population genomics to S. mansoni based on high-coverage resequencing data from 10 global isolates and an isolate of the closely-related Schistosoma rodhaini, which infects rodents. Using population genetic tests, we document genes under directional and balancing selection in S. mansoni that may facilitate adaptation to the human host. Coalescence modeling reveals the speciation of S. mansoni and S. rodhaini as 107.5-147.6KYA, a period which overlaps with the earliest archaeological evidence for fishing in Africa. Our results indicate that S. mansoni originated in East Africa and experienced a decline in effective population size 20-90KYA, before dispersing across the continent during the Holocene. In addition, we find strong evidence that S. mansoni migrated to the New World with the 16-19th Century Atlantic Slave Trade.

引用

页数：13

共 71 条

[1] PREVALENCE OF SCHISTOSOME INFECTIONS WITHIN MOLLUSCAN POPULATIONS - OBSERVED PATTERNS AND THEORETICAL PREDICTIONS [J].

ANDERSON, RM ;

MAY, RM .

PARASITOLOGY, 1979, 79 (AUG) :63-94

[2]

[Anonymous], 1956, ZAMBEZI EXPEDITION D

[3]

[Anonymous], GENOME BIOL EVOL

[4]

[Anonymous], INFECT DIS HUMANS

[5]

[Anonymous], ARK ZOOL A

[6] The genome of the blood fluke Schistosoma mansoni [J].

Berriman, Matthew ;

Haas, Brian J. ;

LoVerde, Philip T. ;

Wilson, R. Alan ;

Dillon, Gary P. ;

Cerqueira, Gustavo C. ;

Mashiyama, Susan T. ;

Al-Lazikani, Bissan ;

Andrade, Luiza F. ;

Ashton, Peter D. ;

Aslett, Martin A. ;

Bartholomeu, Daniella C. ;

Blandin, Gaelle ;

Caffrey, Conor R. ;

Coghlan, Avril ;

Coulson, Richard ;

Day, Tim A. ;

Delcher, Art ;

DeMarco, Ricardo ;

Djikeng, Appolinaire ;

Eyre, Tina ;

Gamble, John A. ;

Ghedin, Elodie ;

Gu, Yong ;

Hertz-Fowler, Christiane ;

Hirai, Hirohisha ;

Hirai, Yuriko ;

Houston, Robin ;

Ivens, Alasdair ;

Johnston, David A. ;

Lacerda, Daniela ;

Macedo, Camila D. ;

McVeigh, Paul ;

Ning, Zemin ;

Oliveira, Guilherme ;

Overington, John P. ;

Parkhill, Julian ;

Pertea, Mihaela ;

Pierce, Raymond J. ;

Protasio, Anna V. ;

Quail, Michael A. ;

Rajandream, Marie-Adele ;

Rogers, Jane ;

Sajid, Mohammed ;

Salzberg, Steven L. ;

Stanke, Mario ;

Tivey, Adrian R. ;

White, Owen ;

Williams, David L. ;

Wortman, Jennifer .

NATURE, 2009, 460 (7253) :352-U65

[7] Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis [J].

Bos, Kirsten I. ;

Harkins, Kelly M. ;

Herbig, Alexander ;

Coscolla, Mireia ;

Weber, Nico ;

Comas, Inaki ;

Forrest, Stephen A. ;

Bryant, Josephine M. ;

Harris, Simon R. ;

Schuenemann, Verena J. ;

Campbell, Tessa J. ;

Majander, Kerttu ;

Wilbur, Alicia K. ;

Guichon, Ricardo A. ;

Steadman, Dawnie L. Wolfe ;

Cook, Della Collins ;

Niemann, Stefan ;

Behr, Marcel A. ;

Zumarraga, Martin ;

Bastida, Ricardo ;

Huson, Daniel ;

Nieselt, Kay ;

Young, Douglas ;

Parkhill, Julian ;

Buikstra, Jane E. ;

Gagneux, Sebastien ;

Stone, Anne C. ;

Krause, Johannes .

NATURE, 2014, 514 (7523) :494-+

[8] Spatial epidemiology of human schistosomiasis in Africa: risk models, transmission dynamics and control [J].

Brooker, Simon .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2007, 101 (01) :1-8

[9] DATING AND CONTEXT OF 3 MIDDLE STONE-AGE SITES WITH BONE POINTS IN THE UPPER SEMLIKI VALLEY, ZAIRE [J].

BROOKS, AS ;

HELGREN, DM ;

CRAMER, JS ;

FRANKLIN, A ;

HORNYAK, W ;

KEATING, JM ;

KLEIN, RG ;

RINK, WJ ;

SCHWARCZ, H ;

SMITH, JNL ;

STEWART, K ;

TODD, NE ;

VERNIERS, J ;

YELLEN, JE .

SCIENCE, 1995, 268 (5210) :548-553

[10] Cytokine interaction and immune responses during Schistosoma mansoni infection [J].

Brunet, LR ;

Dunne, DW ;

Pearce, EJ .

PARASITOLOGY TODAY, 1998, 14 (10) :422-427

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