Focusing-in on microtubules

被引:64
作者
Amos, LA [1 ]
机构
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
关键词
D O I
10.1016/S0959-440X(00)00070-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A good approximation of the atomic structure of a microtubule has been derived from docking the high-resolution structure of tubulin, solved by electron crystallography, into lower resolution maps of whole microtubules. Some structural interactions with other molecules, including nucleotides, drugs, motor proteins and microtubule-associated proteins, can now be predicted.
引用
收藏
页码:236 / 241
页数:6
相关论文
共 57 条
  • [1] Proteolytic mapping of kinesin/ncd-microtubule interface: nucleotide-dependent conformational changes in the loops L8 and L12
    Alonso, MC
    van Damme, J
    Vandekerckhove, J
    Cross, RA
    [J]. EMBO JOURNAL, 1998, 17 (04) : 945 - 951
  • [2] How Taxol® stabilises microtubule structure
    Amos, LA
    Löwe, J
    [J]. CHEMISTRY & BIOLOGY, 1999, 6 (03): : R65 - R69
  • [3] The carboxy-terminal sequence Asp427-Glu432 of β-tubulin plays an important function in axonemal motility
    Audebert, S
    White, D
    Cosson, J
    Huitorel, P
    Eddé, B
    Gagnon, C
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 261 (01): : 48 - 56
  • [4] Brisch E, 1999, J EXP ZOOL, V283, P258, DOI 10.1002/(SICI)1097-010X(19990215)283:3<258::AID-JEZ4>3.0.CO
  • [5] 2-U
  • [6] Role of the kinesin neck linker and catalytic core in microtubule-based motility
    Case, RB
    Rice, S
    Hart, CL
    Ly, B
    Vale, RD
    [J]. CURRENT BIOLOGY, 2000, 10 (03) : 157 - 160
  • [7] 3-DIMENSIONAL RECONSTRUCTION OF TUBULIN IN ZINC-INDUCED SHEETS .2. CONSEQUENCES OF REMOVAL OF MICROTUBULE ASSOCIATED PROTEINS
    CESKA, TA
    EDELSTEIN, SJ
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1984, 175 (03) : 349 - 370
  • [8] The microtubule-associated protein tau cross-links to two distinct sites on each α and β tubulin monomer via separate domains
    Chau, MF
    Radeke, MJ
    de Inés, C
    Barasoain, I
    Kohlstaedt, LA
    Feinstein, SC
    [J]. BIOCHEMISTRY, 1998, 37 (51) : 17692 - 17703
  • [9] Limited flexibility of the inter-protofilament bonds in microtubules assembled from pure tubulin
    Chrétien, D
    Flyvbjerg, H
    Fuller, SD
    [J]. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 1998, 27 (05): : 490 - 500
  • [10] Molecular motors: Kinesin's dynamically dockable neck
    Cross, RA
    [J]. CURRENT BIOLOGY, 2000, 10 (03) : R124 - R126