Focusing-in on microtubules

被引：64
作者：
Amos, LA [1 ]
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 2000年 / 10卷 / 02期
关键词：
D O I：
10.1016/S0959-440X(00)00070-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A good approximation of the atomic structure of a microtubule has been derived from docking the high-resolution structure of tubulin, solved by electron crystallography, into lower resolution maps of whole microtubules. Some structural interactions with other molecules, including nucleotides, drugs, motor proteins and microtubule-associated proteins, can now be predicted.
引用
收藏
页码：236 / 241
页数：6
相关论文
共 57 条
[1]   Proteolytic mapping of kinesin/ncd-microtubule interface: nucleotide-dependent conformational changes in the loops L8 and L12 [J].
Alonso, MC ;
van Damme, J ;
Vandekerckhove, J ;
Cross, RA .
EMBO JOURNAL, 1998, 17 (04) :945-951
[2]   How Taxol® stabilises microtubule structure [J].
Amos, LA ;
Löwe, J .
CHEMISTRY & BIOLOGY, 1999, 6 (03) :R65-R69
[3]   The carboxy-terminal sequence Asp427-Glu432 of β-tubulin plays an important function in axonemal motility [J].
Audebert, S ;
White, D ;
Cosson, J ;
Huitorel, P ;
Eddé, B ;
Gagnon, C .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 261 (01) :48-56
[4]  
Brisch E, 1999, J EXP ZOOL, V283, P258, DOI 10.1002/(SICI)1097-010X(19990215)283:3<258::AID-JEZ4>3.0.CO
[5]  
2-U
[6]   Role of the kinesin neck linker and catalytic core in microtubule-based motility [J].
Case, RB ;
Rice, S ;
Hart, CL ;
Ly, B ;
Vale, RD .
CURRENT BIOLOGY, 2000, 10 (03) :157-160
[7]   3-DIMENSIONAL RECONSTRUCTION OF TUBULIN IN ZINC-INDUCED SHEETS .2. CONSEQUENCES OF REMOVAL OF MICROTUBULE ASSOCIATED PROTEINS [J].
CESKA, TA ;
EDELSTEIN, SJ .
JOURNAL OF MOLECULAR BIOLOGY, 1984, 175 (03) :349-370
[8]   The microtubule-associated protein tau cross-links to two distinct sites on each α and β tubulin monomer via separate domains [J].
Chau, MF ;
Radeke, MJ ;
de Inés, C ;
Barasoain, I ;
Kohlstaedt, LA ;
Feinstein, SC .
BIOCHEMISTRY, 1998, 37 (51) :17692-17703
[9]   Limited flexibility of the inter-protofilament bonds in microtubules assembled from pure tubulin [J].
Chrétien, D ;
Flyvbjerg, H ;
Fuller, SD .
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 1998, 27 (05) :490-500
[10]   Molecular motors: Kinesin's dynamically dockable neck [J].
Cross, RA .
CURRENT BIOLOGY, 2000, 10 (03) :R124-R126
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